抗生素暴露与肝移植后同种异体移植排斥反应和生存的风险:来自三级转诊中心的观察性队列研究。

IF 2.6 4区 医学 Q3 IMMUNOLOGY
Olivia C Smibert, Sara Vogrin, Marie Sinclair, Avik Majumdar, Mohamed Nasra, Dinesh Pandey, Hossein Jahanabadi, Jason A Trubiano, Kate A Markey, Monica A Slavin, Adam Testro, Jason C Kwong
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引用次数: 0

摘要

我们的目标是了解Abx暴露(以及推断的下游肠道微生物组损伤)与肝移植后患者总体生存和排斥反应的关键结局之间是否存在关联。方法:我们进行了一项回顾性队列研究,对462名在多状态肝移植(LTx)服务中接受治疗的肝移植受者进行了7年的研究。抗生素暴露与结果之间的关系通过涉及抗生素谱、持续时间和移植时间的模型进行了测试。采用Cox比例风险回归评价抗生素与生存和排斥反应的关系。结果:该队列中观察到的1年生存率为95% (95% CI: 93%, 97%), 20.8%的患者(96/462)在1年发生排斥反应。在多变量分析中,移植前(p = 0.055)或移植后(p = 0.040)暴露于厌氧靶向抗生素超过14天与1年生存率降低显著相关。在多变量分析中,移植后暴露于任何以厌氧菌为目标的Abx与排斥风险增加显著相关(p = 0.001)。结论:肝移植术前或术后暴露于厌氧谱抗生素与移植后第一年的不良预后相关,并为进一步表征肝移植中抗生素使用、微生物群破坏和细胞免疫之间的关系提供了动力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibiotic Exposure and Risk of Allograft Rejection and Survival After Liver Transplant: An Observational Cohort Study From a Tertiary Referral Centre.

Introduction: Our goal is to understand whether there is an association between Abx exposure-and the inferred downstream damage to the intestinal microbiome-and the key patient outcomes of overall survival and rejection following liver transplant.

Methods: We conducted a retrospective cohort study of 462 liver transplant recipients treated at a multistate liver transplant (LTx) service during a 7-year period. The association between antibiotic exposure and outcome was tested across models that addressed antibiotic spectrum, duration, and timing relative to transplant. Cox proportional hazard regression was used to evaluate the relationship between antibiotics with survival and rejection.

Results: The observed 1-year survival in this cohort was 95% (95% CI: 93%, 97%), and 20.8% of patients (96/462) experienced rejection at 1 year. In multivariable analyses, exposure to anaerobe-targeting antibiotics for longer than 14 days pretransplant (p = 0.055) or posttransplant (p = 0.040) was significantly associated with reduced 1-year survival. In multivariable analyses, exposure to any anaerobe-targeting Abx posttransplant was significantly associated with an increased risk of rejection (p = 0.001).

Conclusions: Exposure to anaerobic spectrum antibiotics either before or after LTx was associated with poor outcomes during the first year posttransplant and provides an impetus to further characterize the relationship between antibiotic use, microbiota disruption, and cellular immunity in liver transplantation.

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来源期刊
Transplant Infectious Disease
Transplant Infectious Disease 医学-传染病学
CiteScore
5.30
自引率
7.70%
发文量
210
审稿时长
4-8 weeks
期刊介绍: Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.
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