通过PI3K/AKT和Hippo通路调控预防化疗诱导的卵巢损伤。

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-03-28 DOI:10.1007/s00520-025-09344-6

Negin Zatalian, Azam Dalman, Hamid Gourabi

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引用次数: 0

摘要

癌症治疗的进步提高了生存率；然而，化疗药物可通过PI3K/AKT和Hippo等途径损害卵巢储备，导致不孕症。传统的保留生育能力的选择有局限性。因此，应该研究预防或减少化疗卵巢副作用的药物。本综述探讨了化疗期间通过调节PI3K/AKT和Hippo通路来保护卵巢储备的治疗方法。当使用环磷酰胺和顺铂治疗时，文章中有33种药物与PI3K/AKT和/或Hippo通路有关，其中大多数靶向PI3K/AKT通路。综上所述，控制PI3K/AKT和Hippo通路，特别是PI3K/AKT通路，可以帮助维持卵巢对这两种化疗药物的储备，并为化疗患者提高生育能力提供希望。

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Preventing chemotherapy-induced ovarian damage through PI3K/AKT and Hippo pathway regulation.

Advances in cancer treatment have increased survival rates; however, chemotherapy drugs can impair ovarian reserve via pathways such as PI3K/AKT and Hippo, leading to infertility. Conventional fertility preservation options have limitations. Therefore, agents that prevent or reduce the ovarian side effects of chemotherapy should be investigated. This review explored treatments for preserving ovarian reserve by regulating the PI3K/AKT and Hippo pathways during chemotherapy. When treated with cyclophosphamide and cisplatin, 33 agents in the articles were implicated in the PI3K/AKT and/or Hippo pathways, most of which target the PI3K/AKT pathway. It can be concluded that controlling both the PI3K/AKT and Hippo pathways, but specifically the PI3K/AKT pathway, can help maintain ovarian reserve against these two chemotherapy drugs and provide hope for increased fertility in patients receiving chemotherapy.

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.