{"title":"代谢重构与翻译后修饰:揭开骨质疏松症骨转换机制的神秘面纱。","authors":"Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong","doi":"10.14336/AD.2025.0123","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoporosis is a metabolic disease characterized by low bone density resulting from abnormal bone metabolism, caused by impaired osteogenesis and/or excessive bone resorption. The coordinated differentiation of osteoblasts (originating from mesenchymal stem cells) and osteoclasts (derived from hematopoietic progenitor cells) is necessary for maintaining normal bone remodeling and homeostasis. Metabolites have been confirmed to regulate cellular behavior through post-translational modifications (PTMs), including acetylation, lactylation, and succinylation. During osteoblast and osteoclast differentiation, progenitor cells undergo metabolic rewiring to meet the energy demands of these biological processes. Consequently, local metabolite profiles and intermediate metabolic products dynamically change during bone remodeling, influencing cell differentiation via PTMs. Given the regulatory role of PTMs in bone metabolism, this review systematically examines PTMs involved in osteoblast and osteoclast differentiation and explores potential avenues for addressing osteoporosis.</p>","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis.\",\"authors\":\"Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong\",\"doi\":\"10.14336/AD.2025.0123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Osteoporosis is a metabolic disease characterized by low bone density resulting from abnormal bone metabolism, caused by impaired osteogenesis and/or excessive bone resorption. The coordinated differentiation of osteoblasts (originating from mesenchymal stem cells) and osteoclasts (derived from hematopoietic progenitor cells) is necessary for maintaining normal bone remodeling and homeostasis. Metabolites have been confirmed to regulate cellular behavior through post-translational modifications (PTMs), including acetylation, lactylation, and succinylation. During osteoblast and osteoclast differentiation, progenitor cells undergo metabolic rewiring to meet the energy demands of these biological processes. Consequently, local metabolite profiles and intermediate metabolic products dynamically change during bone remodeling, influencing cell differentiation via PTMs. Given the regulatory role of PTMs in bone metabolism, this review systematically examines PTMs involved in osteoblast and osteoclast differentiation and explores potential avenues for addressing osteoporosis.</p>\",\"PeriodicalId\":7434,\"journal\":{\"name\":\"Aging and Disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14336/AD.2025.0123\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14336/AD.2025.0123","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis.
Osteoporosis is a metabolic disease characterized by low bone density resulting from abnormal bone metabolism, caused by impaired osteogenesis and/or excessive bone resorption. The coordinated differentiation of osteoblasts (originating from mesenchymal stem cells) and osteoclasts (derived from hematopoietic progenitor cells) is necessary for maintaining normal bone remodeling and homeostasis. Metabolites have been confirmed to regulate cellular behavior through post-translational modifications (PTMs), including acetylation, lactylation, and succinylation. During osteoblast and osteoclast differentiation, progenitor cells undergo metabolic rewiring to meet the energy demands of these biological processes. Consequently, local metabolite profiles and intermediate metabolic products dynamically change during bone remodeling, influencing cell differentiation via PTMs. Given the regulatory role of PTMs in bone metabolism, this review systematically examines PTMs involved in osteoblast and osteoclast differentiation and explores potential avenues for addressing osteoporosis.
期刊介绍:
Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.