炎症桥梁:阿尔茨海默病与骨骼健康之间的相互联系。

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun
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引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory Bridges: Interconnections Between Alzheimer's Disease and Bone Health.

Alzheimer's disease is a neurodegenerative disorder that predominantly affects the elderly and is characterized by complex pathogenesis. Within the unified framework of the ANT, the introduction of B (the disruption of the blood-brain barrier) facilitates communication between the brain and the periphery through the blood-brain barrier. In this context, inflammatory factors act as a bridge, and the neuroinflammation hypothesis is gaining increasing acceptance. This hypothesis involves the abnormal activation of microglia, the release of inflammatory mediators, and damage to astrocytes, which leads to blood-brain barrier impairment and subsequently triggers systemic inflammation. Bone health is associated with conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and periodontitis. This hypothesis establishes a link between Alzheimer's disease and bone health. The present article aims to construct an inflammatory bridge between brain and bone health by summarizing the shared mechanisms between the two, specifically focusing on age-related NLRP3-induced pyroptosis, advanced glycation end products, oxidative stress, macrophage autophagy and lysosomal function, and calcium ion dysregulation. Additionally, it reviews the latest therapeutic approaches to explore potential clinical treatments related to the connection between Alzheimer's disease and bone health through these shared mechanisms.

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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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