姜黄素包封的沸石咪唑酯框架修饰聚醚醚酮通过免疫调节促进成骨能力

IF 8.3 1区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Composites Science and Technology Pub Date : 2025-03-26 DOI:10.1016/j.compscitech.2025.111164

Sihan Ma , Heyi Gong , Duo Sun , Xin Fang , Xiao Han , Yue Liu , Yadi Su , Junqi Wang , Yu Wang , Jinghui Zhao

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引用次数: 0

摘要

控制免疫反应和促进成骨是生物材料植入长期成功的关键。聚醚醚酮（PEEK）在骨科植入物中应用广泛，但其固有的生物惰性和较差的成骨能力限制了其临床应用。在这项研究中，姜黄素（CCM）和沸石咪唑酸框架-8纳米颗粒（ZIF-8 NPs）被引入到PEEK底物上，得到SPEEK-CCM@ZIF-8 （SPZC）体系，该体系通过早期免疫调节增强骨整合。SPEEK-CCM@ZIF-8诱导巨噬细胞向M2表型极化，减少炎症，促进骨髓间充质干细胞（BMSCs）的成骨分化能力，增强PEEK植入物的骨整合和成骨能力。体内评价进一步证实了SPZC增强骨整合的作用。我们的研究结果表明CCM@ZIF-8涂层赋予PEEK良好的成骨能力，SPZC作为种植体具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Curcumin encapsulated zeolitic imidazolate frameworks modified polyetheretherketone promotes osteogenic capacity through immunomodulation

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Curcumin encapsulated zeolitic imidazolate frameworks modified polyetheretherketone promotes osteogenic capacity through immunomodulation

Controlling the immune response and enhancing osteogenesis are essential for the long-term success of biomaterial implantation. Although polyetheretherketone (PEEK) is widely used in orthopedic implants, its inherent bioinertness and poor osteogenic capacity limit its use in clinical applications. In this study, curcumin (CCM) and zeolitic imidazolate frameworks-8 nanoparticles (ZIF-8 NPs) were introduced onto PEEK substrate to obtain the SPEEK-CCM@ZIF-8 (SPZC) system, which enhances osseointegration through early immunomodulation. SPEEK-CCM@ZIF-8 induces macrophage polarization towards M2 phenotype to reduce inflammation, promotes osteogenic differentiation capacity of bone marrow mesenchymal stem cells (BMSCs), and enhances the osseointegration and osteogenic capacity of PEEK implants. In vivo evaluation further confirmed the enhanced osteointegration effect of SPZC. Our results suggest that the CCM@ZIF-8 coating confers good osteogenic capacity to PEEK and that SPZC will have great potential as an implant.

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来源期刊

Composites Science and Technology 工程技术-材料科学：复合

CiteScore

16.20

自引率

9.90%

发文量

611

审稿时长

33 days

期刊介绍： Composites Science and Technology publishes refereed original articles on the fundamental and applied science of engineering composites. The focus of this journal is on polymeric matrix composites with reinforcements/fillers ranging from nano- to macro-scale. CSTE encourages manuscripts reporting unique, innovative contributions to the physics, chemistry, materials science and applied mechanics aspects of advanced composites. Besides traditional fiber reinforced composites, novel composites with significant potential for engineering applications are encouraged.