具有酶样活性的金属锆-有机骨架微马达用于谷胱甘肽检测

IF 4.7 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-03-28 DOI:10.1021/acs.inorgchem.5c00494

Xiaoqing Li, Gui Wang, Dongyang Zhou, Ziwei Lan, Fengling Jiang, Dickon H. L. Ng, Jia Li

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引用次数: 0

摘要

本文报道了一种新型的UiO-67-Co(bpy)0.35微电机，通过在UiO-67-bpy0.35框架中引入与2,2 ‘ -联吡啶-5,5 ’二羧酸连接的钴盐，通过简单的合成后金属化反应合成。Co2+活性位点分解H2O2生成气泡，为UiO-67-Co(bpy)0.35提供动力。同时，UiO-67-Co(bpy)0.35微电机通过在中性条件下催化H2O2生成•OH，表现出强大的过氧化物酶样活性。在此基础上，构建了谷胱甘肽比色检测的传感平台。由于自驱动运动和优异的类过氧化物活性的协同作用，UiO-67-Co(bpy)0.35微电机可以灵敏地检测GSH，检测GSH的分析限低至0.13 μM。本研究为利用合成后金属化法制备高选择性、高灵敏度、高便捷检测谷胱甘肽的Zr(Co)-MOF微电机提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Zirconium Metal–Organic Frameworks as Micromotors with Enzyme-like Activity for Glutathione Detection

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Zirconium Metal–Organic Frameworks as Micromotors with Enzyme-like Activity for Glutathione Detection

Herein, we report a novel UiO-67-Co(bpy)_0.35 micromotor synthesized by a facile postsynthesis metalation via introducing cobalt salts ligated with 2,2′-bipyridine-5,5′dicarboxylic acid into UiO-67-bpy_0.35 framework. The Co²⁺ active sites can decompose H₂O₂ to generate bubbles to power UiO-67-Co(bpy)_0.35. Meanwhile, the UiO-67-Co(bpy)_0.35 micromotor exhibits robust peroxidase-like activity through catalyzing H₂O₂ to generate ^•OH under neutral conditions. Based on this, a sensing platform was constructed for the colorimetric detection of GSH. Due to the synergy of self-driven motion and excellent peroxide-like activity, UiO-67-Co(bpy)_0.35 micromotor can sensitively detect GSH with a low analytic limitation as 0.13 μM for GSH detection. This study provides a new sight of using the postsynthesis metalation method to prepare Zr(Co)-MOF micromotor for highly selective, sensitive, and facile detection of GSH.

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.