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引用次数: 0
摘要
胎儿发育过程中大脑含水量的平衡具有重要的生理意义。水蒸发素在大脑水分平衡和大脑正常发育中发挥着关键作用，对了解和治疗神经发育疾病具有重要意义。在这篇综述中，我们全面概述了水汽素（AQPs）及其在中枢神经系统（CNS）和各种神经发育疾病中的关键作用。具体而言，AQP4、AQP11 和 AQP9 在大脑的水分运输、维持水分平衡以及促进水分在细胞膜上的移动方面发挥着至关重要的作用。这篇综述强调了水通道蛋白表达和功能的紊乱如何可能导致各种神经发育障碍，包括自闭症和脆性 X 综合征。这些干扰会影响血脑屏障的完整性、神经炎症和突触功能，表明水通道蛋白可能是这些疾病的潜在治疗靶点。
Aquaporins: Bridging Normal Brain Development and Neurodevelopmental Disorder Mechanisms.
Homeostasis of water content in the brain during fetal development is of crucial physiological importance. Aquaporins play a critical role in brain water homeostasis, and normal brain development, and have implications for understanding and potentially treating neurodevelopmental disorders. In this review, we provide a comprehensive overview of aquaporins (AQPs) and their critical roles in the central nervous system (CNS) and various neurodevelopmental disorders. Specifically, AQP4, AQP11 and AQP9 play a crucial role in water transport in the brain, maintaining water homeostasis, and facilitating water movement across cell membranes. The review highlights how disruptions in aquaporin expression and function may contribute to various neurodevelopmental disorders, including autism and Fragile X syndrome. These disruptions can affect blood-brain barrier integrity, neuroinflammation, and synaptic function, suggesting that AQPs could be potential therapeutic targets for these conditions.
期刊介绍：
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.
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