来源于上皮细胞的多种肿瘤的新型小鼠模型。

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2025-04-01 DOI:10.14814/phy2.70289

Bin Wang, Lingxiang Wang, Yang Liu, Yasmin Jahan-Mihan, Gordon He, Yuxi Wang, Jie Hu, Jiale Wang, Yan Bi, Baoan Ji

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引用次数: 0

摘要

深入了解病理生理学，从上皮细胞肿瘤的起始到与之相关的结果，对于测试这些疾病的潜在干预措施是必不可少的。然而，由于原始细胞及其转化的复杂性，很少有模型能够做到这一点。我们利用细胞角蛋白19 （Cytokeratin 19, CK19）启动子，通过Cre-ERT介导，在全身上皮细胞中特异性激活KrasG12D并缺失肿瘤抑制基因p53，建立了上皮细胞原始肿瘤小鼠模型。在这个新模型中，多种肿瘤来源于上皮细胞。该模型可以概括肠、胰、肝、肺、皮下等上皮细胞肿瘤的发展过程。该模型适合于研究上皮细胞衍生的肿瘤的病理生理，并可能具有测试干预措施的潜力。

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A novel mouse model of diverse tumors derived from epithelial cells.

A deeper understanding of pathophysiology, from the initiation of tumors of epithelial cells to the outcomes associated with it, is imperative to test potential interventions for these diseases. However, few models can accomplish this because of the complexity of origin cells and their transformation. We established an epithelial cell original tumor mouse model by conditional Kras^G12D activation and tumor suppressor gene p53 deletion specifically in epithelial cells of the whole body using Cytokeratin 19 (CK19) promoter via Cre-ERT mediation. Multiple tumors derived from epithelial cells developed in this novel model. This model can recapitulate the progress of intestinal, pancreatic, liver, lung, and subcutaneous tumors which derive from epithelial cells. This model is suitable for studying the pathophysiology of tumors derived from epithelial cells and may have the potential to test interventions.

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.