壳聚糖纳米颗粒在牙周炎非手术治疗中的最新进展。

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY
Mehrnaz Sadighi Shamami, Mohammad Ekhlaspour, Jameel M A Sulaiman, Radhwan Abdul Kareem, Nahed Mahmood Ahmed Alsultany, Kamyar Nasiri, Naghmeh Shenasa
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引用次数: 0

摘要

由于牙周细胞内细菌内化和慢性炎症激活之间复杂的相互作用,牙周疾病仍然很困难。此外,成人牙齿脱落的主要原因是牙周炎,这是世界上最常见的牙齿疾病之一。预防牙周炎的关键是减少细菌的滋生和物质的产生,这些物质最终会侵蚀牙齿周围和支撑牙齿的组织。此外,用全身给药的抗生素治疗牙周炎有几个缺点。壳聚糖(CS)是一种天然存在的具有抗菌和抗炎特性的聚合物。由于其对厌氧微生物的作用和可能的抗炎特性,CS对治疗牙周病作为药物载体非常感兴趣。由于牙周炎的多因素病理生理,在单一药物递送方法中结合抗菌药物比单独给药更可取,因为当存在许多生物体时,它增加了治疗范围。因此,基于cs的药物输送技术,如凝胶、微颗粒和纳米颗粒(NPs),被创造出来,可以在较长时间内将药物输送到牙周袋。本研究概述了CSNP治疗牙周炎的现有疗效。这一信息可能用于创建基于CSNP治疗牙周感染的代用品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The current advancements in chitosan nanoparticles in the management of non-surgical periodontitis treatment.

Because of the intricate interactions between bacteria internalization in periodontal cells and chronic inflammatory activation, periodontal disorders remain difficult. Furthermore, the primary cause of adult tooth loss is periodontitis, one of the most common dental disorders worldwide. The key to preventing periodontitis has been to reduce the development of bacteria and the generation of substances that eventually erode the tissue surrounding and supporting the teeth. Furthermore, there are several disadvantages to treating periodontitis with antibiotics administered systemically. A naturally occurring polymer with antibacterial and anti-inflammatory properties is chitosan (CS). CS is highly interested in treating periodontal disease as a medicine carrier due to its actions against anaerobic microorganisms and possible anti-inflammatory properties. Due to the multifactorial pathophysiology of periodontitis, combining antimicrobial medications in a single drug delivery method is preferable to administering them separately since it increases the therapeutic range when numerous organisms are present. As a result, CS-based drug delivery technologies, such as gels, micro, and nanoparticles (NPs), were created to transport drugs to the periodontal pocket over an extended period. This research provides an overview of the existing therapeutic benefits of CSNP on periodontitis. This information might be used to create therapeutic substitutes based on CSNP for treating periodontal infections.

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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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