JAK抑制剂治疗酒渣鼻的作用机制及临床进展综述。

IF 3.1 4区医学 Q2 DERMATOLOGY

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-28 DOI:10.1177/12034754251325482

Yulian Hu, Biyu Li, Runlu Hu, Chuang Huang, Kun Huang

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引用次数: 0

摘要

酒渣鼻是一种慢性炎症性疾病，主要影响面部区域，具有复杂的发病机制和多种治疗方案。近年来，随着对酒渣鼻发病机制的深入研究，发现Janus Kinase-Signal Transducer and Activator of Transcription （JAK- stat）信号通路可能参与了酒渣鼻的发生发展，JAK抑制剂有望成为治疗酒渣鼻的新途径。本文就JAK抑制剂治疗酒渣鼻的作用机制、临床疗效及安全性进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Review on the Mechanisms and Clinical Advances of JAK Inhibitors in the Treatment of Rosacea.

Rosacea is a chronic inflammatory disease that primarily affects the facial area, with a complex pathogenesis and a variety of treatment options. In recent years, with deeper research into the pathogenesis of rosacea, it has been discovered that the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway may be involved in the development of rosacea, and JAK inhibitors are expected to become a new therapeutic approach for rosacea. This paper reviews the mechanisms, clinical efficacy, and safety of JAK inhibitors in the treatment of rosacea.

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来源期刊

Journal of Cutaneous Medicine and Surgery 医学-皮肤病学

CiteScore

3.70

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Cutaneous Medicine and Surgery (JCMS) aims to reflect the state of the art in cutaneous biology and dermatology by providing original scientific writings, as well as a complete critical review of the dermatology literature for clinicians, trainees, and academicians. JCMS endeavours to bring readers cutting edge dermatologic information in two distinct formats. Part of each issue features scholarly research and articles on issues of basic and applied science, insightful case reports, comprehensive continuing medical education, and in depth reviews, all of which provide theoretical framework for practitioners to make sound practical decisions. The evolving field of dermatology is highlighted through these articles. In addition, part of each issue is dedicated to making the most important developments in dermatology easily accessible to the clinician by presenting well-chosen, well-written, and highly organized information in a format that is interesting, clearly presented, and useful to patient care.