APP/PS1和APPNL-F/NL-F老年痴呆模型雌雄小鼠寿命的研究

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI:10.1177/13872877251325878

Hannah Roberts, Yimin Fang, Kathleen Quinn, Tiarra Hill, Mackenzie R Peck, Andrzej Bartke, Kevin N Hascup, Erin R Hascup

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引用次数: 0

摘要

阿尔茨海默病（AD）对女性的影响不成比例，但大多数临床前研究都是以男性为中心的。我们对雄性和雌性AD小鼠模型（APP/PS1和APPNL-F/NL-F）及其共同的遗传背景控制（C57BL/6）进行了寿命分析。生存曲线支持基因型之间显著的性别差异。最小寿命显示雄性APP/PS1小鼠的年龄增加，而雄性APPNL-F/NL-F小鼠的年龄减少。最大寿命显示男性的平均年龄增加。此外，中位寿命在性别和基因型之间存在差异。本研究支持两种AD小鼠模型的二态生存，强调需要在两性中研究机制和治疗方法。

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Lifespan of male and female APP/PS1 and APP^NL-F/NL-F mouse models of Alzheimer's disease.

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP^NL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APP^NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.