IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Pei-An Chen, Chiu-Hsuan Cheng, Dah-Ching Ding
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引用次数: 0

摘要

背景和临床意义:耻骨旁腱鞘细胞结节是一种罕见的偶然发现,给诊断带来了挑战。病例介绍:一名 45 岁女性,有高血压和糖尿病史,在一次严重痛经和月经过多后出现发热和寒战。患者称月经大量出血,已持续 2-3 年。体格检查发现会阴部红斑和白色阴道分泌物,宫颈无病变。影像学检查发现右侧卵巢囊肿 15 厘米。实验室检查显示,C反应蛋白(6.37 mg/L)和CA125(88.82 U/mL)水平升高,而其他肿瘤标志物在正常范围内。盆腔超声检查显示子宫后倾,卵巢肿块较大,提示恶性肿瘤。患者接受了右侧输卵管切除术,切除了与右侧盆腔侧壁粘连的15厘米卵巢肿瘤。组织病理学检查发现了一个子宫内膜异位囊肿,内膜腺上皮雌激素受体阳性,并有局灶性粘液变性。还观察到 CD10 阳性的子宫内膜基质细胞和管旁囊肿。此外,还发现了一个源自卵巢蒂的小的Leydig细胞肿瘤,并通过抑制素、钙网素和雄激素受体的阳性染色以及雌激素受体的阴性染色得到了证实。术后恢复顺利,在五周的随访中,患者的激素水平正常,没有出现并发症。结论:本病例强调了在处理卵巢肿块时进行全面组织病理学评估的重要性,以及良性和罕见病理实体(如莱狄格细胞瘤)并存的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Coincidence of Ovarian Endometrioma with Paratubal Leydig Cell Nodules: A Case Report and Literature Review.

Background and Clinical Significance: Paratubal Leydig cell nodules are rare incidental findings that present diagnostic challenges. Case Presentation: A 45-year-old female with a history of hypertension and diabetes mellitus presented with fever and chills following an episode of severe dysmenorrhea and menorrhagia. The patient reported heavy menstrual bleeding, persisting for 2-3 years. Physical examination revealed erythema of the perineum and whitish vaginal discharge, with no cervical lesions. Imaging revealed a 15 cm right ovarian cyst. Laboratory investigations showed elevated C-reactive protein (6.37 mg/L) and CA125 (88.82 U/mL) levels, whereas other tumor markers were within normal limits. A pelvic ultrasound revealed a retroverted uterus and a large ovarian mass suggestive of malignancy. The patient underwent a right salpingo-oophorectomy, during which a 15 cm ovarian tumor adherent to the right pelvic sidewall was excised. Histopathological examination revealed an endometriotic cyst with endometrial glandular epithelium positive for estrogen receptor and focal mucinous metaplasia. CD10-positive endometrial stromal cells and paratubal cysts were also observed. Additionally, a small Leydig cell tumor originated from the ovarian hilum was identified and confirmed by positive staining for inhibin, calretinin, and androgen receptors, as well as negative estrogen receptor staining. The postoperative recovery was uneventful, and at the five-week follow-up, the patient's hormonal levels were normal, and there were no complications. Conclusions: This case highlights the importance of thorough histopathological evaluation in managing ovarian masses and the potential coexistence of benign and rare pathological entities, such as Leydig cell tumors.

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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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