{"title":"一氧化氮和内皮超极化在代谢综合征大鼠肠系膜动脉松弛中的作用","authors":"G I Lobov, I A Tsareva","doi":"10.1007/s10517-025-06345-7","DOIUrl":null,"url":null,"abstract":"<p><p>Changes in the relative contribution of endothelium-produced vasodilators to the modulation of mesenteric artery reactivity were studied in Wistar rats treated with 20% fructose for 16 and 32 weeks. Rats that consumed fructose developed symptoms of metabolic syndrome. Acetylcholine-induced relaxation of phenylephrine-precontracted mesenteric arteries was reduced in rats with metabolic syndrome. The NO-mediated component of acetylcholine-induced relaxation was reduced in these rats. At the same time, arterial relaxation mediated by endothelium-dependent hyperpolarization was increased. Endothelium-independent relaxation of mesenteric arteries to sodium nitroprusside in rats with metabolic syndrome was the same as in the arteries of control rats. These results suggest that the increased contraction of mesenteric arteries caused by phenylephrine in rats with metabolic syndrome is due to decreased NO production by the endothelium. Endothelium-dependent hyperpolarization appears to partially compensates for this dysfunction.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"404-409"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of Nitric Oxide and Endothelial Hyperpolarization in Relaxation of Mesenteric Arteries of Rats with Metabolic Syndrome.\",\"authors\":\"G I Lobov, I A Tsareva\",\"doi\":\"10.1007/s10517-025-06345-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Changes in the relative contribution of endothelium-produced vasodilators to the modulation of mesenteric artery reactivity were studied in Wistar rats treated with 20% fructose for 16 and 32 weeks. Rats that consumed fructose developed symptoms of metabolic syndrome. Acetylcholine-induced relaxation of phenylephrine-precontracted mesenteric arteries was reduced in rats with metabolic syndrome. The NO-mediated component of acetylcholine-induced relaxation was reduced in these rats. At the same time, arterial relaxation mediated by endothelium-dependent hyperpolarization was increased. Endothelium-independent relaxation of mesenteric arteries to sodium nitroprusside in rats with metabolic syndrome was the same as in the arteries of control rats. These results suggest that the increased contraction of mesenteric arteries caused by phenylephrine in rats with metabolic syndrome is due to decreased NO production by the endothelium. Endothelium-dependent hyperpolarization appears to partially compensates for this dysfunction.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"404-409\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06345-7\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06345-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/26 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The Role of Nitric Oxide and Endothelial Hyperpolarization in Relaxation of Mesenteric Arteries of Rats with Metabolic Syndrome.
Changes in the relative contribution of endothelium-produced vasodilators to the modulation of mesenteric artery reactivity were studied in Wistar rats treated with 20% fructose for 16 and 32 weeks. Rats that consumed fructose developed symptoms of metabolic syndrome. Acetylcholine-induced relaxation of phenylephrine-precontracted mesenteric arteries was reduced in rats with metabolic syndrome. The NO-mediated component of acetylcholine-induced relaxation was reduced in these rats. At the same time, arterial relaxation mediated by endothelium-dependent hyperpolarization was increased. Endothelium-independent relaxation of mesenteric arteries to sodium nitroprusside in rats with metabolic syndrome was the same as in the arteries of control rats. These results suggest that the increased contraction of mesenteric arteries caused by phenylephrine in rats with metabolic syndrome is due to decreased NO production by the endothelium. Endothelium-dependent hyperpolarization appears to partially compensates for this dysfunction.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
