hsTnT和NT-proBNP与HIV患者外周动脉疾病的关系：一项多中心丹麦队列研究

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-03-11 DOI:10.3390/biom15030401

Thomas R Holtveg, Anne Marie Reimer Jensen, Ask Bock, Moises Alberto Suarez-Zdunek, Andreas D Knudsen, Børge G Nordestgaard, Shoaib Afzal, Thomas Benfield, Sisse R Ostrowski, Tor Biering-Sørensen, Ruth Frikke-Schmidt, Susanne D Nielsen

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引用次数: 0

摘要

HIV （PWH）患者外周动脉疾病（PAD）的风险较高，高敏感性肌钙蛋白（hsTnT）和NT-pro b型利钠肽（NT-proBNP）可能是PWH患者PAD的有用生物标志物。我们评估了hsTnT和NT-proBNP与流行PAD和新发PAD之间的关系。在基线和2年后检查成人PWH。纳入标准为：(1)基线时hsTnT和NT-proBNP的测量值；(2)基线时踝关节肱指数（ABI）的测量值。以ABI≤0.9定义PAD。我们纳入了1011名PWH患者，其中88名（8.7%）在基线时患有PAD。802例PWH患者中，29例（3.6%）在随访时有新发PAD。在基础模型和调整模型中，hsTnT浓度加倍与PAD患病率相关，OR分别为1.41 （95% CI: 1.02-1.96, p = 0.04）和1.40 （95% CI: 0.99-1.98, p = 0.055）。在未调整的模型中，高hsTnT与新发PAD的风险比为3.39 (95% CI: 1.24-9.27, p = 0.02)，调整后为3.44 （95% CI: 0.98-12.10, p = 0.05）。NT-proBNP与PAD无相关性。因此，hsTnT与较高的PAD患病率和新发PAD风险相关。

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Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort Study.

People with HIV (PWH) have a high risk of peripheral artery disease (PAD), and high-sensitivity troponin (hsTnT) and NT-pro B-type natriuretic peptide (NT-proBNP) may be useful biomarkers for PAD in PWH. We assessed associations between hsTnT and NT-proBNP and both prevalent PAD and de novo PAD. Adult PWH were examined at baseline and after 2 years. Inclusion criteria were (1) measurements of hsTnT and NT-proBNP at baseline and (2) ankle brachial index (ABI) at baseline for prevalent PAD and both visits for de novo PAD. PAD was defined as ABI ≤ 0.9. We included 1011 PWH, and 88 (8.7%) had PAD at baseline. Among 802 PWH, 29 (3.6%) had de novo PAD at follow-up. A doubling in hsTnT concentration was associated with prevalent PAD with an OR 1.41 (95% CI: 1.02-1.96, p = 0.04) and 1.40 (95% CI: 0.99-1.98, p = 0.055) in a base model and an adjusted model, respectively. High hsTnT was associated with a risk ratio of 3.39 (95% CI: 1.24-9.27, p = 0.02) for de novo PAD in an unadjusted model and 3.44 (95% CI: 0.98-12.10, p = 0.05) after adjustments. NT-proBNP was not associated with PAD. Thus, hsTnT was associated with higher odds of prevalent PAD and increased risk of de novo PAD.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.