血浆IL-15和RANTES升高作为慢性静脉溃疡愈合的潜在生物标志物：一项初步研究

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-03-10 DOI:10.3390/biom15030395

Amanda Beneat, Vikki Rueda, Hardik Patel, Zarina Brune, Barbara Sherry, Andrew Shih, Sally Kaplan, Amit Rao, Annette Lee, Asha Varghese, Alisha Oropallo, Betsy J Barnes

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引用次数: 0

摘要

慢性伤口给我们的医疗保健系统带来了很大的负担，并且通常以伤口愈合的炎症期过渡失败为特征。下肢静脉性溃疡（VLUs）在慢性伤口中占最大比例。对11例VLUs患者进行了一项为期12周的初步研究，利用伤口活检的RNA测序和血浆细胞因子水平来确定是否可以识别生物标志物来区分伤口愈合与未愈合。研究发现，慢性伤口与上皮-间质转化（EMT）、软骨和骨形成以及根尖连接调控相关的基因表达增加。血浆细胞因子水平显示出IL-15和RANTES的预测潜力，在伤口愈合的患者中，IL-15和RANTES随着时间的推移而增加。需要进一步的研究来验证这些生物标志物以及其他慢性伤口模型，如糖尿病足溃疡（DFUs）。

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Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study.

Chronic wounds present a large burden to our healthcare system and are typically marked by a failure to transition out of the inflammatory phase of wound healing. Venous leg ulcers (VLUs) represent the largest portion of chronic wounds. A pilot study of eleven (11) patients with VLUs seen over a 12-week period was undertaken utilizing RNA sequencing of wound biopsies and plasma cytokine levels to determine if biomarkers could be identified that would distinguish between wounds which heal versus those that do not. Chronic wounds were found to have increased expression of genes relating to epithelial-to-mesenchymal transition (EMT), cartilage and bone formation, and regulation of apical junction. Plasma cytokine levels showed predictive potential for IL-15 and RANTES, which were found to increase over time in patients with healed wounds. Further research is needed to validate these biomarkers as well as additional study of other chronic wound models, such as diabetic foot ulcers (DFUs).

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.