调节性T细胞在炎症性肝病中的作用

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-03-24 DOI:10.1016/j.autrev.2025.103806

Linjie Yang , Song Guo Zheng

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引用次数: 0

摘要

肝脏是人体最大的消化腺，能参与消化、代谢、排泄、排毒和免疫等功能。慢性肝病，如代谢功能障碍相关的脂肪性肝病（MAFLD）或病毒性肝炎，涉及持续的炎症和由此产生的肝纤维化，最终可能导致肝胆癌（HCC）的发展。炎症是不同类型的肝细胞对细胞信号和炎症死亡的协调反应，这与肝脏内部或肠肝轴和循环的外部介质的损伤途径有关。调节性T细胞（Treg）在控制炎症中起着至关重要的作用，对维持免疫耐受和平衡至关重要。在这篇综述中，我们重点介绍了最近与免疫系统在肝脏炎症中的功能相关的发现，并讨论了Treg细胞在不同肝脏疾病（包括MAFLD、自身免疫性肝炎等）中的作用。

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Role of regulatory T cells in inflammatory liver diseases

The liver is the human body's largest digestive gland, which can participate in digestion, metabolism, excretion, detoxification and immunity. Chronic liver diseases such as metabolic dysfunction-associated fatty liver disease (MAFLD) or viral hepatitis involve ongoing inflammation and resulting liver fibrosis may ultimately lead to the development of hepatobiliary cancers (HCC). Inflammation is the coordinated reaction of different liver cell types to cell signals and death of inflammation, which are linked to injury pathways within the liver or external agents from the gut-liver axis and the circulation. Regulatory T (Treg) cells play a crucial role in controlling inflammation and are essential for maintaining immune tolerance and balance. In this review, we highlight the recent discoveries related to the function of immune systems in liver inflammation and discuss the role of Treg cells in the different liver diseases (including MAFLD, autoimmune hepatitis and others).

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.