{"title":"肥厚性心肌病患者左心室晚期钆增强与房颤相关性的meta分析","authors":"Jiantao Song, Peng Chen, Xiangyue Pan, Bo Chen, Jianhui Zang, Junjie Zhang","doi":"10.1111/echo.70144","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>Atrial fibrillation (AF) is a common complication in individuals with hypertrophic cardiomyopathy (HCM), associated closely with myocardial fibrosis. Late gadolinium enhancement (LGE) detected by cardiac magnetic resonance (CMR) imaging is a marker of myocardial fibrosis and may indicate an increased risk of AF. This meta-analysis was performed to investigate the relationship between left ventricular (LV)-LGE and the occurrence of AF in patients with HCM.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A comprehensive search of the PubMed, Embase, and Web of Science databases was conducted to identify observational studies in which the prevalence or incidence of AF in patients with HCM with and without LV-LGE was compared. Random-effects models were employed to calculate pooled odds ratios (ORs) and mean differences (MDs), accounting for potential heterogeneity across studies.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fourteen reports of 15 observational studies performed with 4 947 patients with HCM were included. The pooled results revealed that CMR-detected LV-LGE was associated with a significantly greater risk of AF (OR, 1.97; 95% confidence interval [CI] 1.41–2.75; <i>p</i> < 0.001, <i>I</i><sup>2</sup> = 60%). Subgroup analyses yielded consistent results across study designs, patient ages, sex distributions, analytical models, and study quality scores. Based on data from six studies in which it was reported, the extent of LV-LGE was greater in patients with AF than in those without AF (MD, 2.83%; 95% CI, 0.69–4.97; <i>p</i> = 0.01, <i>I</i><sup>2</sup> = 66%).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>CMR-detected LV-LGE is associated with a heightened AF risk in patients with HCM.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>CRD42024621359</p>\n </section>\n </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Meta-Analysis of the Association Between Left-Ventricular Late Gadolinium Enhancement on Cardiac MRI and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy\",\"authors\":\"Jiantao Song, Peng Chen, Xiangyue Pan, Bo Chen, Jianhui Zang, Junjie Zhang\",\"doi\":\"10.1111/echo.70144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>Atrial fibrillation (AF) is a common complication in individuals with hypertrophic cardiomyopathy (HCM), associated closely with myocardial fibrosis. Late gadolinium enhancement (LGE) detected by cardiac magnetic resonance (CMR) imaging is a marker of myocardial fibrosis and may indicate an increased risk of AF. This meta-analysis was performed to investigate the relationship between left ventricular (LV)-LGE and the occurrence of AF in patients with HCM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A comprehensive search of the PubMed, Embase, and Web of Science databases was conducted to identify observational studies in which the prevalence or incidence of AF in patients with HCM with and without LV-LGE was compared. Random-effects models were employed to calculate pooled odds ratios (ORs) and mean differences (MDs), accounting for potential heterogeneity across studies.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Fourteen reports of 15 observational studies performed with 4 947 patients with HCM were included. The pooled results revealed that CMR-detected LV-LGE was associated with a significantly greater risk of AF (OR, 1.97; 95% confidence interval [CI] 1.41–2.75; <i>p</i> < 0.001, <i>I</i><sup>2</sup> = 60%). Subgroup analyses yielded consistent results across study designs, patient ages, sex distributions, analytical models, and study quality scores. Based on data from six studies in which it was reported, the extent of LV-LGE was greater in patients with AF than in those without AF (MD, 2.83%; 95% CI, 0.69–4.97; <i>p</i> = 0.01, <i>I</i><sup>2</sup> = 66%).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>CMR-detected LV-LGE is associated with a heightened AF risk in patients with HCM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Trial Registration</h3>\\n \\n <p>CRD42024621359</p>\\n </section>\\n </div>\",\"PeriodicalId\":50558,\"journal\":{\"name\":\"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques\",\"volume\":\"42 4\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/echo.70144\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/echo.70144","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Meta-Analysis of the Association Between Left-Ventricular Late Gadolinium Enhancement on Cardiac MRI and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy
Purpose
Atrial fibrillation (AF) is a common complication in individuals with hypertrophic cardiomyopathy (HCM), associated closely with myocardial fibrosis. Late gadolinium enhancement (LGE) detected by cardiac magnetic resonance (CMR) imaging is a marker of myocardial fibrosis and may indicate an increased risk of AF. This meta-analysis was performed to investigate the relationship between left ventricular (LV)-LGE and the occurrence of AF in patients with HCM.
Methods
A comprehensive search of the PubMed, Embase, and Web of Science databases was conducted to identify observational studies in which the prevalence or incidence of AF in patients with HCM with and without LV-LGE was compared. Random-effects models were employed to calculate pooled odds ratios (ORs) and mean differences (MDs), accounting for potential heterogeneity across studies.
Results
Fourteen reports of 15 observational studies performed with 4 947 patients with HCM were included. The pooled results revealed that CMR-detected LV-LGE was associated with a significantly greater risk of AF (OR, 1.97; 95% confidence interval [CI] 1.41–2.75; p < 0.001, I2 = 60%). Subgroup analyses yielded consistent results across study designs, patient ages, sex distributions, analytical models, and study quality scores. Based on data from six studies in which it was reported, the extent of LV-LGE was greater in patients with AF than in those without AF (MD, 2.83%; 95% CI, 0.69–4.97; p = 0.01, I2 = 66%).
Conclusions
CMR-detected LV-LGE is associated with a heightened AF risk in patients with HCM.
期刊介绍：
Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.
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