IF 3.9 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Faizan E. Mustafa, Bong-Kee Lee
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引用次数: 0

摘要

对于伤口敷料应用,纳米纤维膜在体外培养时必须具有足够的机械强度,以促进细胞生长和基质生成,并能承受体内压力。此外,有效的聚合物药物载体还必须在保持药物稳定性的同时调节和延长药物释放时间。本研究通过热处理(100°C 2 小时)来提高电纺载药庆大霉素聚乙烯醇/壳聚糖(PVA/CS)纳米纤维膜的机械稳定性和药物释放调节特性,从而满足上述要求。不同浓度的庆大霉素电纺丝溶液能纺制出无缺陷且均匀的纳米纤维。利用扫描电子显微镜、傅立叶变换红外光谱和拉伸测试对纳米纤维膜进行了表征,并对其体外生物降解和药物释放行为进行了研究。拉伸试验结果表明,热处理提高了 PVA 和 PVA/CS 纳米纤维的机械强度,而载入庆大霉素的样品在热处理后仍能保持稳定。经过热处理的纳米纤维膜中的庆大霉素表现出可控的药物释放曲线,减少了初始猝灭释放,并可持续释放 25 小时。这些研究结果表明,热处理能有效实现机械稳定性和药物释放调节,是药物负载 PVA/CS 纳米纤维膜生物医学应用中化学交联的一种安全替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Improved Mechanical Stability and Regulated Gentamicin-Release of Polyvinyl Alcohol/Chitosan Nanofiber Membranes via Heat Treatment

Improved Mechanical Stability and Regulated Gentamicin-Release of Polyvinyl Alcohol/Chitosan Nanofiber Membranes via Heat Treatment

For wound dressing applications, nanofiber membranes must have adequate mechanical strength when cultured in vitro for cell ingrowth and matrix production, and the ability to withstand stresses in vivo. Moreover, effective polymeric drug carriers must also regulate and prolong drug release while preserving drug stability. This study addresses these requirements by utilizing heat treatment (100°C for 2 h) to improve the mechanical stability and regulated drug-release characteristics of electrospun gentamicin-loaded polyvinyl alcohol/chitosan (PVA/CS) nanofiber membranes. Electrospinning solutions with varying gentamicin concentrations produced defect-free and uniform nanofibers. The nanofiber membranes were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and tensile testing, and their in vitro biodegradation and drug-release behavior were investigated. Tensile results revealed that heat treatment improved the mechanical strength of PVA and PVA/CS nanofibers, with gentamicin-loaded samples maintaining stability post-treatment. Gentamicin in the heat-treated nanofiber membranes exhibited controlled drug-release profiles, with reduced initial burst release and sustained release for 25 h. Furthermore, drug release was found to occur through the Fickian diffusion mechanism based on the Korsmeyer–Peppas model. These findings demonstrate that heat treatment is effective for achieving mechanical stability and regulated drug release, making it a safe alternative to chemical cross-linking for the biomedical applications of drug-loaded PVA/CS nanofiber membranes.

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来源期刊
Journal of biomedical materials research. Part A
Journal of biomedical materials research. Part A 工程技术-材料科学:生物材料
CiteScore
10.40
自引率
2.00%
发文量
135
审稿时长
3.6 months
期刊介绍: The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.
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