食道神经内分泌癌：一种罕见且具有挑战性的疾病的临床观点

Q4 Medicine

Radiology Case Reports Pub Date : 2025-03-29 DOI:10.1016/j.radcr.2025.03.002

Benayad Aourarh , Aziz Aourarh , Lina Belkouchi , Rachida Saouab , Mohamed Amine Essaoudi

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引用次数: 0

摘要

食道神经内分泌癌（NECs）极为罕见，仅占所有神经内分泌肿瘤的0.04%。这些恶性肿瘤可无症状或表现为消化系统症状，如吞咽困难和腹部不适。由于其罕见，研究有限，导致对其预后和治疗的认识不足，文献数据相互矛盾。本报告提出一个62岁男性慢性吸烟者慢性吞咽困难的情况。诊断评估，包括胃镜检查和CT检查，发现食管下段圆周病变。组织病理学分析证实诊断为低分化大细胞神经内分泌癌。食道NECs是侵袭性肿瘤，人们对其了解甚少。肿瘤大小、淋巴结受累和转移状态是影响治疗决定的关键因素。然而，对于它们的管理并没有既定的指导方针。迫切需要开展广泛的研究，以制定规范的治疗方法，改善高级别食管nec患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease

Neuroendocrine carcinomas (NECs) of the esophagus are exceptionally rare, comprising only 0.04% of all neuroendocrine tumors. These malignancies can remain asymptomatic or manifest through digestive symptoms such as dysphagia and abdominal discomfort. Due to their rarity, limited studies exist, resulting in insufficient knowledge about their prognosis and treatment, with conflicting data in the literature.

This report presents the case of a 62-year-old male chronic smoker with chronic dysphagia. Diagnostic evaluations, including gastroscopy and CT, revealed a circumferential lesion in the lower esophagus. Histopathological analysis confirmed a diagnosis of poorly differentiated large-cell neuroendocrine carcinoma.

Esophageal NECs are aggressive and poorly understood tumors. Tumor size, lymph node involvement, and metastatic status are critical factors influencing treatment decisions. However, there are no established guidelines for their management. Extensive research is urgently needed to develop standardized treatment approaches and improve the prognosis of patients with high-grade esophageal NECs.

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来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.