John Lyne , Francesco Piacenza , Paul Crowley , Justin Smyth , Brian O'Donoghue , Keith Gaynor , Mary Clarke
{"title":"精神病的阴性症状:定性研究的范围综述","authors":"John Lyne , Francesco Piacenza , Paul Crowley , Justin Smyth , Brian O'Donoghue , Keith Gaynor , Mary Clarke","doi":"10.1016/j.schres.2025.03.032","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Negative symptoms in schizophrenia, characterised by the absence or reduction of normal processes, are understudied and effective treatments remain elusive. Qualitative research can provide novel and patient-centred insights into these complex phenomena. This scoping review synthesizes findings from previously published qualitative studies aiming to explore previous results and identify gaps in the published literature.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on MEDLINE, CINAHL, and PsycINFO databases between April and June 2023. Qualitative studies on negative symptoms in psychotic illnesses were eligible for inclusion. Screening and data extraction procedures were performed by two reviewers working independently. Extracted findings were summarised using narrative synthesis based on consensus meetings with the research team.</div></div><div><h3>Results</h3><div>A comprehensive search yielded 4753 articles, with six studies deemed eligible for inclusion. The included studies collectively delved into the experiences, causes, and consequences of negative symptoms. Participants reported a spectrum of negative symptom experiences influenced by social dynamics, societal stigma, and childhood trauma. There was a noticeable interaction between different symptom domains, including negative symptoms, such as motivation and sociability, being influenced by positive symptoms, such as hallucinations and delusions. Studies have also highlighted the impact of prescribed medication and substance use on negative symptoms. Areas needing further qualitative research were identified, including exploring the differentiation between primary and secondary negative symptoms, and gaining a deeper understanding of negative symptom evolution over time.</div></div><div><h3>Conclusions</h3><div>This scoping review provides valuable insights into the subjective experience of negative symptoms and the multifactorial contributory factors to negative symptoms in schizophrenia. The findings, such as the interplay between negative and positive symptoms, emphasise the importance of a holistic understanding of these complex symptoms, which can be informed by qualitative exploration. Furthermore, the qualitative perspectives can enhance future research avenues, and have potential for assisting the development of more effective approaches for treating negative symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 40-49"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Negative symptoms in psychosis: A scoping review of qualitative studies\",\"authors\":\"John Lyne , Francesco Piacenza , Paul Crowley , Justin Smyth , Brian O'Donoghue , Keith Gaynor , Mary Clarke\",\"doi\":\"10.1016/j.schres.2025.03.032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Negative symptoms in schizophrenia, characterised by the absence or reduction of normal processes, are understudied and effective treatments remain elusive. Qualitative research can provide novel and patient-centred insights into these complex phenomena. This scoping review synthesizes findings from previously published qualitative studies aiming to explore previous results and identify gaps in the published literature.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on MEDLINE, CINAHL, and PsycINFO databases between April and June 2023. Qualitative studies on negative symptoms in psychotic illnesses were eligible for inclusion. Screening and data extraction procedures were performed by two reviewers working independently. Extracted findings were summarised using narrative synthesis based on consensus meetings with the research team.</div></div><div><h3>Results</h3><div>A comprehensive search yielded 4753 articles, with six studies deemed eligible for inclusion. The included studies collectively delved into the experiences, causes, and consequences of negative symptoms. Participants reported a spectrum of negative symptom experiences influenced by social dynamics, societal stigma, and childhood trauma. There was a noticeable interaction between different symptom domains, including negative symptoms, such as motivation and sociability, being influenced by positive symptoms, such as hallucinations and delusions. Studies have also highlighted the impact of prescribed medication and substance use on negative symptoms. Areas needing further qualitative research were identified, including exploring the differentiation between primary and secondary negative symptoms, and gaining a deeper understanding of negative symptom evolution over time.</div></div><div><h3>Conclusions</h3><div>This scoping review provides valuable insights into the subjective experience of negative symptoms and the multifactorial contributory factors to negative symptoms in schizophrenia. The findings, such as the interplay between negative and positive symptoms, emphasise the importance of a holistic understanding of these complex symptoms, which can be informed by qualitative exploration. Furthermore, the qualitative perspectives can enhance future research avenues, and have potential for assisting the development of more effective approaches for treating negative symptoms.</div></div>\",\"PeriodicalId\":21417,\"journal\":{\"name\":\"Schizophrenia Research\",\"volume\":\"279 \",\"pages\":\"Pages 40-49\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Schizophrenia Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S092099642500091X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S092099642500091X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Negative symptoms in psychosis: A scoping review of qualitative studies
Introduction
Negative symptoms in schizophrenia, characterised by the absence or reduction of normal processes, are understudied and effective treatments remain elusive. Qualitative research can provide novel and patient-centred insights into these complex phenomena. This scoping review synthesizes findings from previously published qualitative studies aiming to explore previous results and identify gaps in the published literature.
Methods
A systematic search was conducted on MEDLINE, CINAHL, and PsycINFO databases between April and June 2023. Qualitative studies on negative symptoms in psychotic illnesses were eligible for inclusion. Screening and data extraction procedures were performed by two reviewers working independently. Extracted findings were summarised using narrative synthesis based on consensus meetings with the research team.
Results
A comprehensive search yielded 4753 articles, with six studies deemed eligible for inclusion. The included studies collectively delved into the experiences, causes, and consequences of negative symptoms. Participants reported a spectrum of negative symptom experiences influenced by social dynamics, societal stigma, and childhood trauma. There was a noticeable interaction between different symptom domains, including negative symptoms, such as motivation and sociability, being influenced by positive symptoms, such as hallucinations and delusions. Studies have also highlighted the impact of prescribed medication and substance use on negative symptoms. Areas needing further qualitative research were identified, including exploring the differentiation between primary and secondary negative symptoms, and gaining a deeper understanding of negative symptom evolution over time.
Conclusions
This scoping review provides valuable insights into the subjective experience of negative symptoms and the multifactorial contributory factors to negative symptoms in schizophrenia. The findings, such as the interplay between negative and positive symptoms, emphasise the importance of a holistic understanding of these complex symptoms, which can be informed by qualitative exploration. Furthermore, the qualitative perspectives can enhance future research avenues, and have potential for assisting the development of more effective approaches for treating negative symptoms.
期刊介绍:
As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership!
Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue.
The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.