从瓢虫中提取的五种新的斑蝥素衍生物及其治疗神经炎性疾病的潜力

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-26 DOI:10.1016/j.tet.2025.134624

Ke-Ming Li , Wei-Fen Li , Madhu Babu Sura , Guangyi Yang , Yong-Xian Cheng

{"title":"从瓢虫中提取的五种新的斑蝥素衍生物及其治疗神经炎性疾病的潜力","authors":"Ke-Ming Li , Wei-Fen Li , Madhu Babu Sura , Guangyi Yang , Yong-Xian Cheng","doi":"10.1016/j.tet.2025.134624","DOIUrl":null,"url":null,"abstract":"<div><div>Five previously undescribed monoterpenoids, including two 1,2-dimethyl cantharimide-type derivatives (<strong>1</strong> and <strong>2</strong>), one 1-hydroxymethyl-2-methyl cantharimide-type derivative (<strong>3</strong>), and two 1-methyl cantharimide-type derivatives (<strong>4</strong> and <strong>5</strong>), were isolated from the whole bodies of <em>Mylabris cichorii</em> L. Their structures, including absolute configurations, were identified using 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Considering the role of cantharidin derivatives in anti-neuroinflammation, all the compounds were evaluated for their neuroinflammatory activities. Results showed that compound <strong>2</strong> ameliorated LPS-induced neuroinflammation and reduced oxidative stress by targeting mitochondria, thereby decreasing reactive oxygen species (ROS) and pro-inflammatory cytokines. This suggests that compound <strong>2</strong> may be useful in treating neuroinflammatory diseases.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"178 ","pages":"Article 134624"},"PeriodicalIF":2.1000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Five new cantharidin derivatives from the insect Mylabris cichorii and their potential for the treatment of neuroinflammatory diseases\",\"authors\":\"Ke-Ming Li , Wei-Fen Li , Madhu Babu Sura , Guangyi Yang , Yong-Xian Cheng\",\"doi\":\"10.1016/j.tet.2025.134624\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Five previously undescribed monoterpenoids, including two 1,2-dimethyl cantharimide-type derivatives (<strong>1</strong> and <strong>2</strong>), one 1-hydroxymethyl-2-methyl cantharimide-type derivative (<strong>3</strong>), and two 1-methyl cantharimide-type derivatives (<strong>4</strong> and <strong>5</strong>), were isolated from the whole bodies of <em>Mylabris cichorii</em> L. Their structures, including absolute configurations, were identified using 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Considering the role of cantharidin derivatives in anti-neuroinflammation, all the compounds were evaluated for their neuroinflammatory activities. Results showed that compound <strong>2</strong> ameliorated LPS-induced neuroinflammation and reduced oxidative stress by targeting mitochondria, thereby decreasing reactive oxygen species (ROS) and pro-inflammatory cytokines. This suggests that compound <strong>2</strong> may be useful in treating neuroinflammatory diseases.</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"178 \",\"pages\":\"Article 134624\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402025001802\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025001802","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

从赤藓属（Mylabris cichorii L.）中分离得到5个先前未被描述的单萜类化合物，包括2个1,2-二甲基斑蝥酰亚胺类衍生物（1和2）、1-羟甲基-2-甲基斑蝥酰亚胺类衍生物(3)和2个1-甲基斑蝥酰亚胺类衍生物（4和5）。考虑到斑蝥素衍生物在抗神经炎症中的作用，我们对所有化合物的神经炎症活性进行了评估。结果表明，化合物2通过靶向线粒体改善lps诱导的神经炎症，降低氧化应激，从而降低活性氧（ROS）和促炎细胞因子。这表明化合物2可能对治疗神经炎性疾病有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Five new cantharidin derivatives from the insect Mylabris cichorii and their potential for the treatment of neuroinflammatory diseases

查看原文本刊更多论文

Five new cantharidin derivatives from the insect Mylabris cichorii and their potential for the treatment of neuroinflammatory diseases

Five previously undescribed monoterpenoids, including two 1,2-dimethyl cantharimide-type derivatives (1 and 2), one 1-hydroxymethyl-2-methyl cantharimide-type derivative (3), and two 1-methyl cantharimide-type derivatives (4 and 5), were isolated from the whole bodies of Mylabris cichorii L. Their structures, including absolute configurations, were identified using 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Considering the role of cantharidin derivatives in anti-neuroinflammation, all the compounds were evaluated for their neuroinflammatory activities. Results showed that compound 2 ameliorated LPS-induced neuroinflammation and reduced oxidative stress by targeting mitochondria, thereby decreasing reactive oxygen species (ROS) and pro-inflammatory cytokines. This suggests that compound 2 may be useful in treating neuroinflammatory diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.