吡拉西坦在血管性痴呆治疗中的作用机制

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-03-24 DOI:10.1016/j.bbr.2025.115551

Hayder M. Al-kuraishy , Ali I. Al-Gareeb , Duaa Eliwa , Athanasios Alexiou , Marios Papadakis , Mubarak Alruwaili , Gaber El-Saber Batiha

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引用次数: 0

摘要

吡拉西坦是γ氨基丁酸的环衍生物，通过抑制神经炎症对神经退行性疾病具有神经保护作用。吡拉西坦增强乙酰胆碱对毒蕈碱受体的作用，从而改善学习和记忆。此外，吡拉西坦通过调节离子通道增加参与认知功能的不同神经递质的活性。令人兴奋的是，吡拉西坦通过抑制纤维蛋白原增加红细胞的变形能力和减少红细胞对血管内皮的粘附来改善血流；因此，它可以改善微循环，并可用于血管性痴呆（VaD）的管理。此外，吡拉西坦通过减少线粒体功能障碍和氧化应激改善VaD患者的认知功能。因此，吡拉西坦对VaD具有神经保护作用。然而，吡拉西坦对VaD发生发展的确切神经保护机制尚不完全清楚。因此，本综述试图讨论吡拉西坦在VaD中的潜在作用。

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The mechanistic role of piracetam in the management of vascular dementia

Piracetam is a cyclic derivative of gamma aminobutyric acid, has a neuroprotective effect against neurodegenerative disease by inhibiting neuroinflammation. Piracetam augments the effect of acetylcholine on the muscarinic receptors thereby improving learning and memory. In addition, piracetam through modulation of ion channels increases the activity of different neurotransmitters involved in cognitive function. Excitingly, piracetam improves blood flow by increasing erythrocyte deformability and reducing adhesion of erythrocytes to the vascular endothelium by inhibiting fibrinogen; thus, it improves microcirculation and can be used in the management of vascular dementia (VaD). Also, piracetam improves cognitive function in VaD by reducing mitochondrial dysfunction and oxidative stress. Hence, piracetam has a neuroprotective effect against VaD. However, the exact neuroprotective mechanism of piracetam against the development and progression of VaD was not fully clarified. Consequently, this review attempts to discuss the potential effect of piracetam in VaD.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.