儿童中令人痛苦的精神病样经历的聚类概况及其与遗传风险、产前大麻暴露和社会环境特征的关联

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-03-28 DOI:10.1016/j.schres.2025.03.034

Qingyue Yuan , Yinxian Chen , Ying Xu , Lina V. Dimitrov , Benjamin B. Risk , Elaine F. Walker , Anke Huels , Benson S. Ku

{"title":"儿童中令人痛苦的精神病样经历的聚类概况及其与遗传风险、产前大麻暴露和社会环境特征的关联","authors":"Qingyue Yuan , Yinxian Chen , Ying Xu , Lina V. Dimitrov , Benjamin B. Risk , Elaine F. Walker , Anke Huels , Benson S. Ku","doi":"10.1016/j.schres.2025.03.034","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Distressing psychotic-like experiences (PLEs) in children are associated with an increased risk for psychiatric disorders. Recent studies suggest that different domains of psychotic symptoms could be associated with distinct risk factors, but less is known about PLEs. This study clustered PLEs into subgroups and explored the genetic and environmental characteristics associated with these profiles.</div></div><div><h3>Methods</h3><div>Data from children (<em>N</em> = 11,854) recruited as part of the Adolescent Brain and Cognitive Development Study v5.1 assessed PLEs using 21-items from the Prodromal-Questionnaire-Brief Child Version. K-medoid clustering of PLEs was conducted among children with at least one distressing PLE item at baseline (<em>n</em> = 3155). Associations of polygenic risk scores for schizophrenia (PRS-SCZ) and social-environmental characteristics with PLE subgroups were estimated using generalized multinomial mixed models, adjusting for age, sex, race/ethnicity, parental education, income-to-needs ratio, and family history of psychosis.</div></div><div><h3>Results</h3><div>We identified three distressing PLE subgroups: hallucinatory-like (<em>n</em> = 1110), paranoid-like (<em>n</em> = 1229), and multiple PLE domains (<em>n</em> = 816). Compared to those without any distressing PLEs (<em>n</em> = 8699), those with hallucinatory-like PLE were more likely to have had prenatal cannabis exposure (Odds Ratio (OR) = 1.578, 95 % CI: 1.231–2.023); paranoid-like individuals had higher PRS-SCZ (OR = 1.080, 95 % CI: 1.001–1.166); those with multiple PLE domains participated in less physical activities (OR = 0.880, 95 % CI: 0.803–0.964). All groups were more likely to have experienced greater childhood adversity and worse school environments.</div></div><div><h3>Conclusions</h3><div>We found that those with different aspects of distressing PLEs had distinct and similar genetic and environmental characteristics. These results suggest that it may be important to consider the heterogeneity of PLE in conceptualizing the development of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 119-127"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cluster profiles of distressing psychotic-like experiences among children and associations with genetic risk, prenatal cannabis exposure, and social-environmental characteristics\",\"authors\":\"Qingyue Yuan , Yinxian Chen , Ying Xu , Lina V. Dimitrov , Benjamin B. Risk , Elaine F. Walker , Anke Huels , Benson S. Ku\",\"doi\":\"10.1016/j.schres.2025.03.034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Distressing psychotic-like experiences (PLEs) in children are associated with an increased risk for psychiatric disorders. Recent studies suggest that different domains of psychotic symptoms could be associated with distinct risk factors, but less is known about PLEs. This study clustered PLEs into subgroups and explored the genetic and environmental characteristics associated with these profiles.</div></div><div><h3>Methods</h3><div>Data from children (<em>N</em> = 11,854) recruited as part of the Adolescent Brain and Cognitive Development Study v5.1 assessed PLEs using 21-items from the Prodromal-Questionnaire-Brief Child Version. K-medoid clustering of PLEs was conducted among children with at least one distressing PLE item at baseline (<em>n</em> = 3155). Associations of polygenic risk scores for schizophrenia (PRS-SCZ) and social-environmental characteristics with PLE subgroups were estimated using generalized multinomial mixed models, adjusting for age, sex, race/ethnicity, parental education, income-to-needs ratio, and family history of psychosis.</div></div><div><h3>Results</h3><div>We identified three distressing PLE subgroups: hallucinatory-like (<em>n</em> = 1110), paranoid-like (<em>n</em> = 1229), and multiple PLE domains (<em>n</em> = 816). Compared to those without any distressing PLEs (<em>n</em> = 8699), those with hallucinatory-like PLE were more likely to have had prenatal cannabis exposure (Odds Ratio (OR) = 1.578, 95 % CI: 1.231–2.023); paranoid-like individuals had higher PRS-SCZ (OR = 1.080, 95 % CI: 1.001–1.166); those with multiple PLE domains participated in less physical activities (OR = 0.880, 95 % CI: 0.803–0.964). All groups were more likely to have experienced greater childhood adversity and worse school environments.</div></div><div><h3>Conclusions</h3><div>We found that those with different aspects of distressing PLEs had distinct and similar genetic and environmental characteristics. These results suggest that it may be important to consider the heterogeneity of PLE in conceptualizing the development of psychosis.</div></div>\",\"PeriodicalId\":21417,\"journal\":{\"name\":\"Schizophrenia Research\",\"volume\":\"278 \",\"pages\":\"Pages 119-127\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Schizophrenia Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0920996425000982\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0920996425000982","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

儿童痛苦的精神样经历（ple）与精神障碍的风险增加有关。最近的研究表明，精神病症状的不同领域可能与不同的危险因素有关，但对ple的了解较少。本研究将ple聚类成亚群，并探讨了与这些亚群相关的遗传和环境特征。方法来自儿童的数据（N = 11,854），作为青少年大脑和认知发展研究v5.1的一部分，使用前驱症状-问卷-简要儿童版中的21个项目对其进行评估。在基线时至少有一个痛苦的PLE项目的儿童中对PLE进行k -中聚类（n = 3155）。使用广义多项混合模型，对年龄、性别、种族/民族、父母受教育程度、收入需求比和精神病家族史进行调整，估计精神分裂症多基因风险评分（PRS-SCZ）和社会环境特征与PLE亚组的关联。结果我们确定了三个令人痛苦的PLE亚组：幻觉样（n = 1110），偏执样（n = 1229）和多个PLE域（n = 816）。与没有任何痛苦PLE的人（n = 8699）相比，有幻觉样PLE的人更有可能在产前接触大麻（优势比(OR) = 1.578, 95% CI: 1.231-2.023）；偏执样个体的PRS-SCZ较高（OR = 1.080, 95% CI: 1.001 ~ 1.166）；有多个PLE域的患者体育活动较少（OR = 0.880, 95% CI: 0.803 ~ 0.964）。所有群体都更有可能经历更大的童年逆境和更糟糕的学校环境。结论不同方面的痛苦性创伤具有不同的遗传特征和相似的环境特征。这些结果表明，在概念化精神病的发展时，考虑PLE的异质性可能是重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cluster profiles of distressing psychotic-like experiences among children and associations with genetic risk, prenatal cannabis exposure, and social-environmental characteristics

Background

Distressing psychotic-like experiences (PLEs) in children are associated with an increased risk for psychiatric disorders. Recent studies suggest that different domains of psychotic symptoms could be associated with distinct risk factors, but less is known about PLEs. This study clustered PLEs into subgroups and explored the genetic and environmental characteristics associated with these profiles.

Methods

Data from children (N = 11,854) recruited as part of the Adolescent Brain and Cognitive Development Study v5.1 assessed PLEs using 21-items from the Prodromal-Questionnaire-Brief Child Version. K-medoid clustering of PLEs was conducted among children with at least one distressing PLE item at baseline (n = 3155). Associations of polygenic risk scores for schizophrenia (PRS-SCZ) and social-environmental characteristics with PLE subgroups were estimated using generalized multinomial mixed models, adjusting for age, sex, race/ethnicity, parental education, income-to-needs ratio, and family history of psychosis.

Results

We identified three distressing PLE subgroups: hallucinatory-like (n = 1110), paranoid-like (n = 1229), and multiple PLE domains (n = 816). Compared to those without any distressing PLEs (n = 8699), those with hallucinatory-like PLE were more likely to have had prenatal cannabis exposure (Odds Ratio (OR) = 1.578, 95 % CI: 1.231–2.023); paranoid-like individuals had higher PRS-SCZ (OR = 1.080, 95 % CI: 1.001–1.166); those with multiple PLE domains participated in less physical activities (OR = 0.880, 95 % CI: 0.803–0.964). All groups were more likely to have experienced greater childhood adversity and worse school environments.

Conclusions

We found that those with different aspects of distressing PLEs had distinct and similar genetic and environmental characteristics. These results suggest that it may be important to consider the heterogeneity of PLE in conceptualizing the development of psychosis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.