2000-2019年美国宫颈癌发病率趋势

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-03-22 DOI:10.1016/j.cegh.2025.102002

Yu-yi Ou , Zi-Jun Lin , Santosh Chokkakula , Siomui Chong , Xiaohua Xu , Liying Huang , Andrew In-Cheong Si Md , Jiang Yong , Chengliang Yin , Jun Lyu , Xiao-bin Huang

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引用次数: 0

摘要

宫颈癌仍然是全球和美国的一个重大公共卫生问题。了解疾病发生的模式和确定高危人群至关重要。本研究旨在评估年龄、月经周期和出生队列对宫颈癌发病率的影响，重点是确定最脆弱的人口群体。方法使用监测、流行病学和最终结果（SEER） 17数据库进行回顾性队列分析，其中包括2000年至2019年诊断的宫颈癌病例。采用年龄-时期-队列（APC）模型和连接点分析来检查不同年龄组、种族、肿瘤分期和大小的宫颈癌发病率趋势。计算年龄标准化发病率（asir）及其95%置信区间（ci）以评估时间和人口统计学变化。结果2000 - 2019年宫颈癌发病率呈波动趋势，先下降后略有上升。2013年后的年增长率为0.3% （95% CI: - 0.7% - 1.4%）。年龄特异性分析显示，20-24岁年龄组发病率显著下降，40-44岁年龄组发病率上升，在研究期间达到高峰。局部和远处肿瘤分期以及较小肿瘤的发病率也有所降低。结论2000年至2019年，宫颈癌发病率在不同年龄组之间存在差异，40-44岁人群的易感性明显增加。这些发现强调了针对弱势群体的有针对性干预策略的重要性，并为宫颈癌发病率的时间动态提供了见解。

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Trends in cervical cancer incidence in the United States from 2000-2019

Introduction

Cervical cancer remains a significant public health issue globally and in the United States (US). Understanding the patterns of disease occurrence and identifying at-risk populations is crucial. This study aimed to assess the impact of age, menstrual cycle, and birth cohort on cervical cancer incidence, with a focus on identifying the most vulnerable demographic groups.

Methods

A retrospective cohort analysis was conducted using the Surveillance, Epidemiology, and End Results (SEER) 17 database, which included cervical cancer cases diagnosed between 2000 and 2019. Age-period-cohort (APC) modeling and joinpoint analysis were employed to examine trends in cervical cancer incidence across various age groups, racial categories, tumor stages, and sizes. Age-standardized incidence rates (ASIRs) and their 95 % confidence intervals (CIs) were calculated to assess temporal and demographic variations.

Results

Cervical cancer incidence demonstrated a fluctuating trend from 2000 to 2019, with an initial decline followed by a slight increase from 2013 onward. The annual growth rate post-2013 was 0.3 % (95 % CI: −0.7 %–1.4 %). Age-specific analysis revealed a significant decrease in incidence for the 20–24 age group and an increase for the 40–44 age group, which reached its peak during the study period. A reduction in incidence was also observed for localized and distant tumor stages, as well as smaller tumors.

Conclusion

Between 2000 and 2019, cervical cancer incidence varied across age groups, with individuals aged 40–44 years showing a marked increase in susceptibility. These findings highlight the importance of targeted intervention strategies for vulnerable populations and provide insights into the temporal dynamics of cervical cancer incidence.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.