香榧假皮中的二萜类化合物及其细胞毒性

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-26 DOI:10.1016/j.tet.2025.134621

Jun-Ru Guo , Min-Jian Dong , Cheng-Xin Sun , Jun Dai , Mao-Sheng Zhang , Shi-Ji Xiao

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引用次数: 0

摘要

从香榧假皮中分离得到3个新的二萜类化合物（2、3、5），2个新的天然产物（1、7）及3个类似物。通过详细的核磁共振分析对这些化合物进行了结构解析，并使用ECD技术确认了绝对构型。对8β，18-二羟基-9(11),13-abietadien-12-one(6)的NMR数据进行了修正。采用MTT法评价分离化合物对SW1990、A549、MDB-MA-231和HCT116细胞的细胞毒作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diterpenoids from the aril of Torreya grandis and their cytotoxicity

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Diterpenoids from the aril of Torreya grandis and their cytotoxicity

Three new diterpenoids (2, 3, and 5), two new natural products (1 and 7), along with three analogues were isolated from the aril of Torreya grandis. The structural elucidation of these compounds was achieved through detailed NMR analysis, and the absolute configurations were confirmed using ECD techniques. The NMR data of 8β,18-dihydroxy-9(11),13-abietadien-12-one (6) was revised. The cytotoxic effects of the isolated compounds on SW1990, A549, MDB-MA-231, and HCT116 cells were evaluated using the MTT assay.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.