在几内亚比绍农村进行皮内bcg疫苗接种的进修培训增加了bcg瘢痕形成率

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-03-25 DOI:10.1016/j.vaccine.2025.127039

Julie Odgaard Vedel , Oides Furtado , Laerte Lima Almeida , Jailson Sydenei Dias Martins , Sanne Møller Thysen , Andreas Møller Jensen , Igualdino Da Silva Borges , Ane Bærent Fisker

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引用次数: 0

摘要

背景正确的疫苗接种技术对卡介苗疤痕的发生至关重要。在接种过卡介苗疫苗的儿童中，卡介苗疤痕与较低的死亡率相关。目的比较卡介苗技术培训前后接种儿童卡介苗瘢痕的流行情况。方法通过卫生和人口监测系统评估几内亚比绍农村bcg -scar的流行情况。在一项随机试验中，三个地区（干预区）卫生机构的工作人员接受了卡介苗接种技术的进修培训。在第四个区域（控制区）没有实施培训。在logistic回归模型中，我们比较了训练前后接种疫苗的儿童的疤痕患病率。结果干预区bcg -scar患病率从75%增加到92%（比值比(OR) = 4.19, 95% CI 2.92 ~ 6.01），对照组从71%增加到78% (OR = 1.43, 95% CI 0.89 ~ 2.29) （p值：0.001）。结论接种技术培训后卡介苗结疤率增高。

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Refresher training in administering intradermal BCG-vaccine increased BCG-scarring rates in rural Guinea-Bissau

Background

A correct vaccination technique is important for developing BCG scars. Having a BCG scar is associated with lower mortality among BCG-vaccinated children.

Aim

To compare BCG-scar prevalences among children vaccinated before and after refresher training in BCG vaccination technique.

Methods

BCG-scar prevalence is assessed through a health and demographic surveillance system in rural Guinea-Bissau. In the context of a randomised trial, staff at health facilities in three regions (intervention area) received refresher training on BCG vaccination technique. In a fourth region (control area) no training was implemented. In logistic regression models, we compared scar prevalence among children vaccinated before and after the training.

Results

BCG-scar prevalence increased from 75 % to 92 % (odds ratio (OR) = 4.19, 95 %CI 2.92–6.01) in the intervention area and from 71 % to 78 % (OR = 1.43, 95 %CI 0.89–2.29) in the control area (p-value for same increase: <0.001).

Conclusion

BCG scarring rates increased after training in vaccination technique.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.