用于工程动态细胞形状的可激酶电路的光学控制

IF 17.6 1区物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY

Nature Physics Pub Date : 2025-03-28 DOI:10.1038/s41567-025-02810-2

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引用次数: 0

摘要

光开关酶在介导活细胞中的分子活化方面具有很大的前景，但它们在非线性网络中实现多功能控制的全部潜力仍未被探索。现在，光学控制在动物细胞分裂中涉及的一种关键酶上得到了证明，通过生物化学手段破解内源性信号通路，可以实现多种动态细胞形状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Optical control of an excitable enzyme circuit for engineering dynamic cell shapes

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Optical control of an excitable enzyme circuit for engineering dynamic cell shapes

Light-switchable enzymes hold great promise for mediating molecular activations in living cells, yet their full potential in realizing versatile controls in nonlinear networks remains unexplored. Now, optical control is demonstrated over a key enzyme involved in animal cell division, and a diverse array of dynamic cell shapes is achieved by biochemically hacking an endogenous signalling circuit.

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来源期刊

Nature Physics 物理-物理：综合

CiteScore

30.40

自引率

2.00%

发文量

349

审稿时长

4-8 weeks

期刊介绍： Nature Physics is dedicated to publishing top-tier original research in physics with a fair and rigorous review process. It provides high visibility and access to a broad readership, maintaining high standards in copy editing and production, ensuring rapid publication, and maintaining independence from academic societies and other vested interests. The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.