蛋白质甜点的机制

IF 17.6 1区物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY

Nature Physics Pub Date : 2025-03-28 DOI:10.1038/s41567-025-02826-8

Qian-Yuan Tang

引用次数: 0

摘要

蛋白质依靠动态灵活性作为生命的分子机器发挥作用。现在，人工智能预测和力学实验揭示了特定蛋白质位点的突变如何调节酶催化，从而推进了蛋白质设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The mechanics of protein sweet spots

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The mechanics of protein sweet spots

Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.

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来源期刊

Nature Physics 物理-物理：综合

CiteScore

30.40

自引率

2.00%

发文量

349

审稿时长

4-8 weeks

期刊介绍： Nature Physics is dedicated to publishing top-tier original research in physics with a fair and rigorous review process. It provides high visibility and access to a broad readership, maintaining high standards in copy editing and production, ensuring rapid publication, and maintaining independence from academic societies and other vested interests. The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.