子宫内膜异位症的铁下垂:中医干预和机制见解。

IF 5.5
The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI:10.1142/S0192415X25500156
Dingli Lan, Shuping Huang, Jing Li, Shilang Zhou, Jianli Deng, Shuiyun Qin, Ting Zhou, Fengyun Meng, Weihong Li
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引用次数: 0

摘要

子宫内膜异位症(EMS)是一种慢性雌激素依赖性炎症性疾病,影响5-10%的育龄妇女,其特征是子宫内膜组织在子宫外生长。铁代谢失调导致铁离子在病变部位积聚,导致氧化应激和促炎反应,促进EMS的进展。EMS中铁下垂的机制主要涉及铁积累、脂质过氧化和谷胱甘肽过氧化物酶4活性的丧失。这些机制赋予异位组织对铁下垂的抵抗力,并促进细胞存活和增殖。中医已经证明了调节铁下垂的治疗潜力。研究表明,中药单体可能通过调节铁转运蛋白和抗氧化防御机制来调节铁死亡。中医方剂根据EMS的不同阶段采用不同的治疗策略:在早期阶段,它们促进铁下垂以控制病变生长,而在后期阶段,它们抑制铁下垂以减少氧化应激和炎症,以改善生殖健康和减缓疾病进展。本研究通过总结铁下垂在其病理机制中的作用以及中医药在调节铁下垂中的研究成果,为EMS的潜在治疗策略提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights.

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5-10% of women of reproductive age, characterized by the growth of endometrial tissue on the outside of the uterus. The dysregulation of iron metabolism leads to the accumulation of iron ions at the lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote the progression of EMS. The mechanisms underlying ferroptosis in EMS primarily involve iron accumulation, lipid peroxidation, and loss of glutathione peroxidase 4 activity. These mechanisms confer resistance to ferroptosis within the ectopic tissues and facilitate cell survival and proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown that TCM monomers may regulate ferroptosis by modulating iron transport proteins and anti-oxidant defense mechanisms. TCM formulas employ distinct treatment strategies depending on the stage of EMS: in the early stages, they promote ferroptosis to control lesion growth, whereas in the later stages, they inhibit ferroptosis to reduce oxidative stress and inflammation in order to improve reproductive health and slow disease progression. This study provides a new perspective on potential therapeutic strategies for the management of EMS by summarizing the role of ferroptosis in its pathological mechanisms and reviewing findings on the use of TCM in regulating ferroptosis.

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