多发性骨髓瘤双易位1例：t（11;14）和t（14;16）。

IF 0.6 4区医学 Q4 HEMATOLOGY

Journal of Hematopathology Pub Date : 2025-03-27 DOI:10.1007/s12308-025-00626-w

Mina Meseha, Vishw Patel, Kirolos Sekla, Ping Yang, David Coffey

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引用次数: 0

摘要

多发性骨髓瘤是一种克隆性浆细胞恶性肿瘤，通常以复杂的细胞遗传学异常为特征，影响预后和治疗策略。本报告描述了一名63岁男性kappa轻链多发性骨髓瘤，通过FISH分析发现罕见的双易位，涉及t（11;14）和t（14;16）。本病例强调了这种基因异常的临床意义及其对疾病进展和治疗决策的影响。

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A rare case of multiple myeloma with double translocations: t(11;14) and t(14;16).

Multiple myeloma is a clonal plasma cell malignancy often characterized by complex cytogenetic abnormalities that influence prognosis and treatment strategies. This report describes a 63-year-old male with kappa light chain multiple myeloma and a rare finding of double translocation involving t(11;14) and t(14;16), detected by FISH analysis. This case emphasizes the clinical implications of such genetic abnormalities and their impact on disease progression and therapeutic decisions.

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来源期刊

Journal of Hematopathology HEMATOLOGYPATHOLOGY-PATHOLOGY

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Journal of Hematopathology aims at providing pathologists with a special interest in hematopathology with all the information needed to perform modern pathology in evaluating lymphoid tissues and bone marrow. To this end the journal publishes reviews, editorials, comments, original papers, guidelines and protocols, papers on ancillary techniques, and occasional case reports in the fields of the pathology, molecular biology, and clinical features of diseases of the hematopoietic system. The journal is the unique reference point for all pathologists with an interest in hematopathology. Molecular biologists involved in the expanding field of molecular diagnostics and research on lymphomas and leukemia benefit from the journal, too. Furthermore, the journal is of major interest for hematologists dealing with patients suffering from lymphomas, leukemias, and other diseases. The journal is unique in its true international character. Especially in the field of hematopathology it is clear that there are huge geographical variations in incidence of diseases. This is not only locally relevant, but due to globalization, relevant for all those involved in the management of patients.