重新审视快速眼动睡眠行为障碍与帕金森病进展之间的关系。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-03-19 DOI:10.1016/j.parkreldis.2025.107801

Xin-Tao Wu, Qiu-Han Xu

引用次数: 0

摘要

这项研究挑战了快速眼动睡眠行为障碍（RBD）是严重帕金森病（PD）进展的标志的假设。通过双样本孟德尔随机化，我们发现PD进展和RBD之间没有因果关系。有趣的是，RBD对运动和复合PD进展表现出潜在的保护作用，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Revisiting the association between REM sleep behavior disorder and Parkinson's disease progression.

This study challenges the assumption that REM sleep behavior disorder (RBD) is a marker of severe Parkinson's disease (PD) progression. Using two-sample Mendelian randomization, we found no causal link between PD progression and RBD. Interestingly, RBD exhibited a potential protective effect on motor and composite PD progression, warranting further investigation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.