当归叶抗糖基化活性的研究。

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-03-20 DOI:10.3390/molecules30061394

Yuno Takemoto, Takashi Kikuchi, Wenjun Qi, Mi Zhang, Kouharu Otsuki, Wei Li

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引用次数: 0

摘要

对一小部分日本凉茶提取物进行了筛选，发现当归叶具有显著的抗糖基化活性。LC-MS分析鉴定了20种化合物，包括7种黄酮类化合物、5种苯丙素和8种香豆素衍生物，基于它们的色谱行为和破碎模式。用甲基乙二醛（MGO）对反应混合物进行甲醇洗脱后的部分进行进一步的LC-MS分析，发现槲皮素3- o -葡萄糖苷是叶片抗糖基化活性的关键化合物。

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Anti-Glycation Activities of Angelica keiskei Leaves.

The screening of a small library of Japanese herbal tea extracts revealed significant anti-glycation activity in the leaves of Angelica keiskei. LC-MS analysis led to the identification of twenty compounds in this herb tea, including seven flavonoids, five phenylpropanoids, and eight coumarin derivatives, based on their chromatographic behavior and fragmentation patterns. Further LC-MS analysis of the methanol-eluted fraction after incubation with methylglyoxal (MGO) was performed on the reaction mixture, revealing quercetin 3-O-glucoside to be a key compound contributing to the anti-glycation activity of the leaves.

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.