非酒精性脂肪性肝病儿童神经精神合并症的横断面回顾性研究

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2025-03-27 DOI:10.1177/00099228251330113

Katherine F Sweeny, Christine K Lee, Paul D Mitchell, Shavonne Osiakwan, Cosette Scott, Maureen M Jonas

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引用次数: 0

摘要

本单中心横断面回顾性图表综述旨在确定非酒精性脂肪性肝病（NAFLD）儿童与一般人群相比神经精神（NP）障碍的患病率。在2006年至2016年评估的儿童中，测定诊断时NP障碍的患病率。将NP障碍患病率与2016年全国儿童健康调查（NSCH）报告的患病率进行比较。254名NAFLD患儿中有24.3%报告至少有1种NP障碍，而非NSCH患儿中这一比例为16.9%(相对危险度[RR] = 1.44；P < 0.0001)。更多的儿童有智力障碍（ID） (4.5% vs 0.8%；RR = 5.43, P < 0.0001)，抑郁症(3.9% vs 2.2%；RR = 1.82, P = 0.0009)，或自闭症谱系障碍（ASD） (3.3% vs 2.0%；RR = 1.67, P = 0.047)。在我们的队列中，1 NP障碍的患病率为29.4%，而在NSCH中为22.3% (RR = 1.32；P = .007)。与一般人群相比，NAFLD儿童有更高的NP障碍发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Cross-Sectional Retrospective Review of Neuropsychiatric Comorbidities in Children With Non-Alcoholic Fatty Liver Disease.

This single-center cross-sectional retrospective chart review sought to define the prevalence of neuropsychiatric (NP) disorders among children with non-alcoholic fatty liver disease (NAFLD) compared to the general population. The prevalence rate of NP disorders was determined at diagnosis among children evaluated from 2006 to 2016. The NP disorder prevalence rates were compared to those reported in the 2016 National Survey of Children's Health (NSCH). 24.3% of 254 children with NAFLD reported to have at least 1 NP disorder compared to 16.9% of those in NSCH (relative risk [RR] = 1.44; P < .0001). More children had intellectual disability (ID) (4.5% vs 0.8%; RR = 5.43, P < .0001), depression (3.9% vs 2.2%; RR = 1.82, P = .0009), or autism spectrum disorder (ASD) (3.3% vs 2.0%; RR = 1.67, P = .047) in the Boston Children's Hospital (BCH) NAFLD cohort. The prevalence of 1 NP disorder was 29.4% in our cohort compared to 22.3% in NSCH (RR = 1.32; P = .007). Children with NAFLD have a higher rate of NP disorders compared to the general population.

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.