不同血糖状态下c反应蛋白-甘油三酯葡萄糖指数与卒中风险的关系：来自中国健康与退休纵向研究（CHARLS）的见解

IF 8.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Diabetology Pub Date : 2025-03-26 DOI:10.1186/s12933-025-02686-9

Guijun Huo, Yao Tang, Zhanao Liu, Junjie Cao, Zhichao Yao, Dayong Zhou

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引用次数: 0

摘要

目的：c反应蛋白-甘油三酯-葡萄糖指数（CTI）已被提出作为胰岛素抵抗和炎症的一种新的生物标志物。然而，CTI与卒中风险之间的关系，特别是在不同血糖状态的个体中，仍不清楚。方法：从中国健康与退休纵向研究（CHARLS）中招募10443名中老年受试者。主要终点是卒中事件的发生。CTI计算公式为0.412* Ln (CRP [mg/L]) + Ln (TG [mg/dl] × FPG [mg/dl])/2。应用Kaplan-Meier曲线、Cox比例风险模型和受限三次样条分析，探讨性别、年龄和血糖状态对CTI与卒中风险的影响。结果：在中位9年的随访期间，960名（9.2%）参与者经历了中风。我们的研究结果显示CTI与卒中发生之间存在显著的正线性关系。男性和女性之间的相关性相似，尽管女性的HR倾向于高于男性（HR 1.22, 95% CI 1.09, 1.36）（HR 1.15, 95% CI 1.02, 1.29），中年参与者（HR 1.25, 95% CI 1.11, 1.41）和老年参与者（HR 1.12, 95% CI 1.00, 1.26）。在不同的血糖状态下，高水平的CTI被发现与正常血糖调节（NGR）（HR 1.33, 95% CI 1.11, 1.59）和糖尿病前期（Pre-DM）（HR 1.20, 95% CI 1.04, 1.39）的个体中风风险增加有关。然而，在糖尿病（DM）患者中没有观察到这种关联。结论：我们的研究结果显示CTI与卒中发生之间存在显著的正线性关系。CTI与中风之间的关联在男性和女性之间相似，在中老年参与者中也相似。在不同的血糖状态下，NGR和前期糖尿病患者的相关性显著。

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Association between C-reactive protein-triglyceride glucose index and stroke risk in different glycemic status: insights from the China Health and Retirement Longitudinal Study (CHARLS).

Objective: C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, the association between CTI and the risk of stroke, particularly in individuals with different glycemic status, remains unclear.

Methods: A total of 10,443 middle-aged and elderly participants were enrolled from the China Health and Retirement Longitudinal Study (CHARLS). The primary endpoint was the occurrence of stroke events. The CTI was calculated using the formula 0.412* Ln (CRP [mg/L]) + Ln (TG [mg/dl] × FPG [mg/dl])/2. The Kaplan-Meier curves, Cox proportional hazard models, and restricted cubic spline analysis were applied to explore the association between CTI and the risk of stroke according to gender, age and glycemic status.

Results: During a median follow-up of 9 years, 960 (9.2%) participants experienced a stroke. Our findings revealed a significant positive linear relationship between CTI and the occurrence of stroke. The association was similar between male and female, despite the HR tended to be higher in females (HR 1.22, 95% CI 1.09, 1.36) than males (HR 1.15, 95% CI 1.02, 1.29), and similar in middle-aged (HR 1.25, 95% CI 1.11, 1.41) and elderly participants (HR 1.12, 95% CI 1.00, 1.26). In different glycemic status, high levels of CTI were found to be linked to an increased risk of stroke in individuals with normal glucose regulation (NGR) (HR 1.33, 95% CI 1.11, 1.59) and prediabetes mellitus (Pre-DM) (HR 1.20, 95% CI 1.04, 1.39). However, this association was not observed in individuals with diabetes mellitus (DM).

Conclusions: Our findings revealed a significant positive linear relationship between CTI and the occurrence of stroke. The association between CTI and stroke was similar between male and female, and similar in middle-aged and elderly participants. In different glycemic status, the association was significant in individuals with NGR and Pre-DM.

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.