X-linked inhibitor of apoptosis protein （XIAP）在肿瘤发生中的关键作用。

IF 8.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-03-27 DOI:10.1007/s10495-025-02101-4

Hui Fan, Jiyuan Liu, Xiangyan Hu, Jiye Cai, Bo Su, Jinhuan Jiang

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引用次数: 0

摘要

X-linked inhibitor of apoptosis protein （XIAP）是凋亡蛋白家族中最有效的内源性成员。XIAP通过直接结合caspases、激活核因子κB （NF-κB）通路等多种信号通路，抑制死亡受体通路和凋亡线粒体通路，发挥抗凋亡作用。这些过程与肿瘤的发生和进展密切相关，使XIAP成为多种类型癌症的治疗靶点。本文将首先综述XIAP的结构特点和生物学功能，然后介绍其对肿瘤的作用以及XIAP靶向抑制剂的概况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

X-linked inhibitor of apoptosis protein (XIAP) is the most potent endogenous member of the inhibitor of apoptosis protein family. XIAP exerts its anti-apoptotic effects by inhibiting both the death receptor pathway and mitochondrial pathway of apoptosis through various mechanisms such as directly binding to caspases, activating the nuclear factor kappa B (NF-κB) pathway, and other signaling pathways. These processes are closely related to tumor development and progression, making XIAP a therapeutic target for various types of cancer. This article will first review the structural characteristics and biological functions of XIAP, followed by its effects on tumors and an overview of XIAP-targeted inhibitors.

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.