精神药物引起的体重增加和端粒长度

The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI:10.1002/pu.31299

Y. W. Francis Lam Pharm.D., FCCP

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引用次数: 0

摘要

研究表明，端粒缩短、染色体末端的保护性帽状结构以及炎症与细胞寿命缩短有关，因此与几种与年龄相关的疾病有关（Gavia-García等人，2021）。一项荟萃分析报告了端粒长度较短与几种精神疾病之间的关联，包括焦虑、双相情感障碍、抑郁症、创伤后应激障碍和精神病（Darrow et al., 2016）。

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Psychotropic-induced weight gain and telomere length

Research suggests that shortening of telomeres, protective cap-like structures at the ends of chromosomes, as well as inflammation, are associated with decreased cellular lifespan, and as such have been implicated in several age-related medical conditions (Gavia-García et al., 2021). A meta-analysis has reported an association between shorter telomere length and several psychiatric conditions, including anxiety, bipolar disorder, depression, post-traumatic stress disorder, and psychosis (Darrow et al., 2016).

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The Brown University Psychopharmacology Update

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