{"title":"队列研究表明早期开始氯氮平的益处","authors":"","doi":"10.1002/pu.31297","DOIUrl":null,"url":null,"abstract":"<p>A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of <i>Lancet Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cohort study suggests benefit of earlier initiation of clozapine\",\"authors\":\"\",\"doi\":\"10.1002/pu.31297\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of <i>Lancet Psychiatry</i>.</p>\",\"PeriodicalId\":22275,\"journal\":{\"name\":\"The Brown University Psychopharmacology Update\",\"volume\":\"36 5\",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Brown University Psychopharmacology Update\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/pu.31297\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cohort study suggests benefit of earlier initiation of clozapine
A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of Lancet Psychiatry.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
