Robert W. Regenhardt, Penina P. Krieger, Anna K. Bonkhoff, Markus D. Schirmer, Christopher G. Favilla, Vincent M. Tutino, Alvin S. Das, Adam A. Dmytriw, Raj Gupta, James D. Rabinov, Christopher J. Stapleton, Thabele M. Leslie-Mazwi, Aman B. Patel, Eng H. Lo, Natalia S. Rost
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Diffusion-weighted imaging (DWI) lesions underwent manual segmentation and registration onto a standard brain space for topographical mapping. The presence of PH postintervention was determined. Associations between infarct topography, clinical characteristics, and PH were evaluated.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 165 patients (median age: 69; 56% female) were identified. Intravenous alteplase was administered to 52%, 70% achieved thrombolysis in cerebral infarction 2b-3 reperfusion, and 8% had PH postintervention. The preintervention DWI lesions were 48% (38%–60%) white matter, 23% (6%–47%) cortex, and 15% (4%–28%) basal ganglia. Basal ganglia infarct volume was independently associated with PH (adjusted odds ratio = 1.342, 95% confidence interval 1.002–1.797, <i>p</i> = 0.049), accounting for white matter and cortex infarct volume, among other key factors. Basal ganglia infarct volume was associated with susceptibility-weighted imaging vessel sign (beta<sub>adjusted</sub> = 0.233, <i>p</i> = 0.006) and the National Institutes of Health Stroke Scale (beta<sub>adjusted</sub> = 0.220, <i>p</i> = 0.012), controlling for other factors.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Preintervention basal ganglia infarct volume may provide important insights into the risk of PH after intervention. Improved understanding of the biology of basal ganglia infarction and hemorrhagic transformation has implications for the management of patients undergoing EVT and may represent a future therapeutic target for neuroprotective strategies.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 2","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Parenchymal Hematoma After Endovascular Thrombectomy Is Associated With Pretreatment Basal Ganglia Infarct Volume\",\"authors\":\"Robert W. Regenhardt, Penina P. Krieger, Anna K. Bonkhoff, Markus D. Schirmer, Christopher G. Favilla, Vincent M. Tutino, Alvin S. Das, Adam A. Dmytriw, Raj Gupta, James D. Rabinov, Christopher J. Stapleton, Thabele M. Leslie-Mazwi, Aman B. Patel, Eng H. Lo, Natalia S. 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Parenchymal Hematoma After Endovascular Thrombectomy Is Associated With Pretreatment Basal Ganglia Infarct Volume
Background and Purpose
Parenchymal hematomas (PHs) represent an important complication in ischemic stroke after endovascular thrombectomy (EVT), but the risk factors are incompletely understood. Neuroimaging data preintervention, such as infarct topography, may help elucidate predisposing factors and inform more nuanced patient care intra- and postprocedurally.
Methods
Large vessel occlusion patients with pre-EVT MRI were included from a single quaternary center. Diffusion-weighted imaging (DWI) lesions underwent manual segmentation and registration onto a standard brain space for topographical mapping. The presence of PH postintervention was determined. Associations between infarct topography, clinical characteristics, and PH were evaluated.
Results
A total of 165 patients (median age: 69; 56% female) were identified. Intravenous alteplase was administered to 52%, 70% achieved thrombolysis in cerebral infarction 2b-3 reperfusion, and 8% had PH postintervention. The preintervention DWI lesions were 48% (38%–60%) white matter, 23% (6%–47%) cortex, and 15% (4%–28%) basal ganglia. Basal ganglia infarct volume was independently associated with PH (adjusted odds ratio = 1.342, 95% confidence interval 1.002–1.797, p = 0.049), accounting for white matter and cortex infarct volume, among other key factors. Basal ganglia infarct volume was associated with susceptibility-weighted imaging vessel sign (betaadjusted = 0.233, p = 0.006) and the National Institutes of Health Stroke Scale (betaadjusted = 0.220, p = 0.012), controlling for other factors.
Conclusions
Preintervention basal ganglia infarct volume may provide important insights into the risk of PH after intervention. Improved understanding of the biology of basal ganglia infarction and hemorrhagic transformation has implications for the management of patients undergoing EVT and may represent a future therapeutic target for neuroprotective strategies.
期刊介绍：
Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on:
MRI
CT
Carotid Ultrasound and TCD
SPECT
PET
Endovascular Surgical Neuroradiology
Functional MRI
Xenon CT
and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!
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