eIF4F复合物中eIF4E家族的蛋白质多样性

IF 2.2 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2025-03-27 DOI:10.1134/S0006297924603721

Viktoriya V. Kolesnikova, Oleg S. Nikonov, Phat Tien Do, Ekaterina Yu. Nikonova

{"title":"eIF4F复合物中eIF4E家族的蛋白质多样性","authors":"Viktoriya V. Kolesnikova, Oleg S. Nikonov, Phat Tien Do, Ekaterina Yu. Nikonova","doi":"10.1134/S0006297924603721","DOIUrl":null,"url":null,"abstract":"<p>In eukaryotes, translation initiation occurs by the cap-dependent mechanism. Each translated mRNA must be pre-bound by the translation initiation factor eIF4E. All isoforms of this factor are combined into one family. The review considers natural diversity of the eIF4E isoforms in different organisms, provides structural information about them, and describes their functional role in the processes, such as oncogenesis, participation in the translation of certain mRNAs under stress, and selective use of the individual isoforms by viruses. In addition, this review briefly describes the mechanism of cap-dependent translation initiation and possible ways to regulate the eIF4E function.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 1 supplement","pages":"S60 - S85"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Proteins Diversity of the eIF4E Family in the eIF4F Complex\",\"authors\":\"Viktoriya V. Kolesnikova, Oleg S. Nikonov, Phat Tien Do, Ekaterina Yu. Nikonova\",\"doi\":\"10.1134/S0006297924603721\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In eukaryotes, translation initiation occurs by the cap-dependent mechanism. Each translated mRNA must be pre-bound by the translation initiation factor eIF4E. All isoforms of this factor are combined into one family. The review considers natural diversity of the eIF4E isoforms in different organisms, provides structural information about them, and describes their functional role in the processes, such as oncogenesis, participation in the translation of certain mRNAs under stress, and selective use of the individual isoforms by viruses. In addition, this review briefly describes the mechanism of cap-dependent translation initiation and possible ways to regulate the eIF4E function.</p>\",\"PeriodicalId\":483,\"journal\":{\"name\":\"Biochemistry (Moscow)\",\"volume\":\"90 1 supplement\",\"pages\":\"S60 - S85\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry (Moscow)\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0006297924603721\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow)","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0006297924603721","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

在真核生物中，翻译起始是通过帽依赖机制发生的。每个翻译mRNA必须被翻译起始因子eIF4E预结合。该因子的所有同型异构体被组合成一个家族。这篇综述考虑了不同生物体中eIF4E亚型的自然多样性，提供了有关它们的结构信息，并描述了它们在过程中的功能作用，例如肿瘤发生，参与胁迫下某些mrna的翻译，以及病毒对单个亚型的选择性使用。此外，本文还简要介绍了帽依赖翻译起始的机制和调控eIF4E功能的可能途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Proteins Diversity of the eIF4E Family in the eIF4F Complex

In eukaryotes, translation initiation occurs by the cap-dependent mechanism. Each translated mRNA must be pre-bound by the translation initiation factor eIF4E. All isoforms of this factor are combined into one family. The review considers natural diversity of the eIF4E isoforms in different organisms, provides structural information about them, and describes their functional role in the processes, such as oncogenesis, participation in the translation of certain mRNAs under stress, and selective use of the individual isoforms by viruses. In addition, this review briefly describes the mechanism of cap-dependent translation initiation and possible ways to regulate the eIF4E function.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).