从孤对到强力分子：非亲核孤对如何控制催化剂的亲核性

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-03-13 DOI:10.1021/acs.joc.4c0255710.1021/acs.joc.4c02557

Ziyuan Gong, Alberto Smith, Christian J. Harrison, Emma Trapnell and Sheryl L. Wiskur*,

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引用次数: 0

摘要

在硅基化模型反应中，采用孤对-π相互作用改变了三种异硫脲催化剂的反应活性。尽管孤对π相互作用是一种相对弱的相互作用，但与成键步骤协同工作使得相互作用可以改变醇硅基化反应中催化剂固有的亲核性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

From Lone Pairs to Power Players: How Non-nucleophilic Lone Pairs Can Control the Nucleophilicity of a Catalyst

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From Lone Pairs to Power Players: How Non-nucleophilic Lone Pairs Can Control the Nucleophilicity of a Catalyst

A lone pair-π interaction was employed to alter the reactivity of three isochalcogenourea catalysts in a model silylation reaction. Even though a lone pair-π interaction is a relatively weak interaction, working cooperatively with a bond-forming step allowed the interaction to alter the reactivity of the catalyst over the inherent nucleophilicity in an alcohol silylation reaction.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.