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IF 6.8 1区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Medicinal Chemistry Pub Date : 2025-03-27 DOI:10.1021/acs.jmedchem.5c00772

Stephanie Federico

引用次数: 0

摘要

P2X4 受体参与免疫和炎症过程，强效拮抗剂可用于治疗、研究和诊断。本视点总结了强效和选择性 P2X4 拮抗剂的发现，这些发现使研究人员更接近获得有价值的 PET 示踪剂来研究 P2X4 受体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Towards P2X4 Positron Emission Tomography Tracing

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Towards P2X4 Positron Emission Tomography Tracing

The P2X4 receptor is involved in immunological and inflammatory processes and potent antagonists are potentially useful for therapeutic, investigational, and diagnostic purposes. This Viewpoint summarizes the discovery of potent and selective P2X4 antagonists that bring researchers closer to obtaining valuable PET tracers for studying the P2X4 receptor.

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来源期刊

Journal of Medicinal Chemistry 医学-医药化学

CiteScore

4.00

自引率

11.00%

发文量

804

审稿时长

1.9 months

期刊介绍： The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.