Sıla Nur Usta, Emre Avcı, Eda Doğuş, Maria Teresa Arias-Moliz
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Influence of 2-Hydroxyisocaproic Acid on Growth Factor Release From Dentin in Regenerative Endodontic Treatments. A Laboratory Study.
This study aimed to assess the effect of 2-hydroxyisocaproic acid (HICA) on the TGF-β1, IGF-1, BMP-7, and VEGF-A release from root canal dentin, compared to calcium hydroxide (CH) and double antibiotic paste (DAP) in regenerative endodontic treatments (RET). Forty-eight single-canal teeth were prepared to mimic immature teeth and treated according to the RET protocol. Teeth were divided into three experimental (HICA, CH, and DAP) and one control (non-dressed) group. TGF-β1, BMP-7, IGF-1 and VEGF-A levels were measured using an ELISA kit on days 1 and 7. Significantly higher TGF-β1 release was found in the HICA and CH groups than in the other groups (p < 0.05). While the levels of growth factor release were notably higher on day 7 in the HICA group (p < 0.05), the values remained consistent across both time intervals within the control group. HICA proved to be effective as an intracanal medicament in enhancing the release of growth factors.
期刊介绍：
The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues.
The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses.
The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.
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