体外循环对小儿心脏手术后迟发性高乳酸血症的影响。

IF 0.5 4区 医学 Q4 SURGERY
Behzat Tüzün, Servet Ergün, Şerife Özalp, Mehmet Akif Önalan, Berra Zümrüt Tan Recep, Eymen Recep, İbrahim Cansaran Tanıdır, Erkut Öztürk, Ali Can Hatemi
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引用次数: 0

摘要

背景:本研究旨在探讨手术和术后参数对儿科患者心脏手术后迟发性高乳酸血症(LOHL)的影响。方法:159例室间隔缺损患者(男77例,女82例;平均年龄:8.0±8.6岁;在2020年8月至2023年2月期间回顾性检查了1至48岁)。结果:体外循环(CPB)时间、主动脉交叉钳夹时间、CPB流量组间差异无统计学意义(p=0.916、p=0.729、p=0.699)。CPB后第一血气分氧压(PaO2)差异有统计学意义(p=0.017)。CPB术后第一次动脉血气乳酸水平1组为1.74±0.61 mmol/L, 2组为3.01±1.63 mmol/L(术后6 h动脉血气p2值1组为129.22±61.20 mmHg, 2组为156.07±64.49 mmHg, p=0.046)。结论:cpb后早期缺血性高乳酸血症的发生可能影响LOHL的发生。组织水平的微循环改变可能在LOHL的病因中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of cardiopulmonary bypass on late-onset hyperlactatemia after pediatric cardiac surgery.

Background: This study aimed to investigate the effect of operative and postoperative parameters on late-onset hyperlactatemia (LOHL) after cardiac surgery in the pediatric patient population.

Methods: One hundred fifty-nine ventricular septal defect patients (77 males, 82 females; mean age: 8.0±8.6 years; range, 1 to 48 years) were retrospectively examined between August 2020 and February 2023. Patients with the highest lactate value measured between 6 to 12 h postoperatively <3 mmol/L were defined as Group 1, and those with lactate values ≥3 mmol/L (LOHL) were included in Group 2.

Results: Cardiopulmonary bypass (CPB) time, aortic cross-clamp time, and CPB flow did not differ between groups (p=0.916, p=0.729, and p=0.699, respectively). The difference between partial oxygen pressure (PaO2) in the first blood gas obtained after CPB was statistically significant (p=0.017). The lactate level measured in the first arterial blood gas obtained after CPB was 1.74±0.61 mmol/L in Group 1 and 3.01±1.63 mmol/L in Group 2 (p<0.001). The PaO2 in the arterial blood gas measured at 6 h postoperatively was 129.22±61.20 mmHg in Group 1 and 156.07±64.49 mmHg in Group 2 (p=0.046).

Conclusion: The development of hyperlactatemia due to ischemia in the early post-CPB period may affect the development of LOHL. Microcirculatory changes at the tissue level may play a role in the etiology of LOHL.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
98
审稿时长
3-8 weeks
期刊介绍: The Turkish Journal of Thoracic and Cardiovascular Surgery is an international open access journal which publishes original articles on topics in generality of Cardiac, Thoracic, Arterial, Venous, Lymphatic Disorders and their managements. These encompass all relevant clinical, surgical and experimental studies, editorials, current and collective reviews, technical know-how papers, case reports, interesting images, How to Do It papers, correspondences, and commentaries.
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