体内高频超声弹性成像检测圆锥角膜局部生物力学减弱。

IF 2.6 3区 医学 Q2 OPHTHALMOLOGY
Sunny Kwok, Xueliang Pan, Manqi Pan, Zihao Chen, Madison Ammon, Andrew Hendershot, Jun Liu
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引用次数: 0

摘要

目的:角膜的体内生物力学表征仍然是一个挑战。我们已经开发了一种高分辨率超声弹性成像技术,称为眼脉冲弹性成像(OPE),用于测量每次心跳时眼压(IOP)脉动引起的角膜变形。在本研究中,我们旨在比较圆锥角膜患者和正常人的角膜轴向应变(CASs),并评估高分级圆锥角膜中CAS的空间定位。方法:选取40例圆锥角膜患者(63眼)和40例正常人(80眼)作为研究对象。使用Vevo2100高频超声系统对每只眼睛进行4次超声测量。每次测量在8秒内获得1000次连续b模式扫描。采用超声散斑跟踪算法对角膜轴向位移和应变进行量化。结果:圆锥角膜的CAS强度显著高于正常角膜(-0.13%±0.09% vs -0.06%±0.04%,P < 0.001),且分级越高,CAS强度越高(P < 0.001)。3级和4级圆锥角膜的CAS具有较大的空间差异,圆锥中心的菌株高于其周围区域。结论:我们的研究结果表明,高频超声弹性成像能够检测和量化圆锥角膜在每次心跳时IOP自然波动时比正常角膜更大的变形,并检测到锥体区域变形更大的空间方差。翻译相关性:高分辨率超声可以为快速、空间分辨的角膜生物力学特征提供灵敏的工具,以帮助圆锥角膜的检测和诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.

Purpose: In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-resolution ultrasound elastography technique, termed ocular pulse elastography (OPE), to measure corneal deformation in response to the intraocular pressure (IOP) pulsation at each heartbeat. In this study, we aimed to compare corneal axial strains (CASs) between patients with keratoconus and normal subjects and evaluate the spatial mapping of CAS in high grade keratoconus.

Methods: Forty patients with keratoconus (63 eyes) and 40 normal controls (80 eyes) were enrolled in this study. Each eye underwent 4 ultrasound measurements using the Vevo2100 high-frequency ultrasound system. Each measurement acquired 1000 continuous B-mode scans in 8 seconds. Corneal axial displacements and strains were quantified using an ultrasound speckle tracking algorithm.

Results: CAS magnitude was significantly higher in keratoconus than normal corneas (-0.13% ± 0.09% vs. -0.06% ± 0.04%, P < 0.001) with an increasing trend in higher grades (P < 0.001). CAS in keratoconus corneas had a greater spatial variance as higher strains were observed in the cone center than its surrounding regions in grade 3 and 4 keratoconus corneas.

Conclusions: Our results showed that high-frequency ultrasound elastography was able to detect and quantify the larger deformation of keratoconus corneas than normal corneas in response to the natural fluctuations of IOP at each heartbeat, and it also detected the spatial variance showing greater deformation in the cone region.

Translational relevance: High-resolution ultrasound may provide a sensitive tool for quick, spatially resolved characterization of corneal biomechanics to aid keratoconus detection and diagnosis.

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来源期刊
Translational Vision Science & Technology
Translational Vision Science & Technology Engineering-Biomedical Engineering
CiteScore
5.70
自引率
3.30%
发文量
346
审稿时长
25 weeks
期刊介绍: Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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