儿童及青少年精神科住院患者多药治疗预测因素及相关因素:一项回顾性研究。

IF 2.9 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI:10.1097/JCP.0000000000001981
Sean Lynch, Timothy Becker, Parul Shanker, Dalton Martin, Paige Staudenmaier, Alicia Leong, Timothy Rice
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引用次数: 0

摘要

目的/背景:青少年精神病药物处方率有所增加,其中很大一部分是精神病综合用药的接受者。多种用药可增加多种不良后果的风险。先前的研究试图确定多药的预测因素/相关因素是异质的。本研究旨在研究精神科住院青年中与多药相关的因素,并测量在COVID-19大流行期间多药的变化。方法/步骤:对1101例患者的病历进行回顾性分析。收集社会人口学及临床资料,采用SPSS软件进行统计分析。发现/结果:约三分之一的患者接受精神药物综合治疗;这组患者中男性、白人患者比例较高,亚洲/南亚患者比例较低。他们平均住院次数更多,住院时间更长,更有可能被诊断为冲动/行为障碍、发育障碍或双相情感障碍。他们在住院期间接受躁动药物治疗的可能性是其他人的两倍。回归模型确定多重用药的积极预测因素为有暴力史和较高的精神住院次数。负面预测因素包括非白人种族。在整个研究期间,多药率相对稳定,未发现COVID-19大流行的影响。意义/结论:小儿精神科多药治疗相对常见,可能与较差的预后相关。某些社会人口学和临床特征可以帮助临床医生预测哪些年轻人可能有多重用药的风险。纵向研究表明,以检查结果的综合药房,使提供者可以有效地实施明智的处方做法在社区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictors and Correlates of Psychiatric Polypharmacy Among Child and Adolescent Psychiatric Inpatients: A Retrospective Study.

Purpose/background: Rates of prescriptions of psychotropic medications to youth have increased, a significant proportion of which are recipients of psychiatric polypharmacy. Polypharmacy can increase the risk of multiple negative outcomes. Prior studies attempting to identify predictors/correlates of polypharmacy have been heterogeneous. This study aimed to examine factors associated with polypharmacy among psychiatrically hospitalized youth, and measure changes in polypharmacy over time throughout the COVID-19 pandemic.

Methods/procedures: The medical records of 1101 patients were reviewed. Sociodemographic and clinical information was collected and analyzed using SPSS.

Findings/results: About one-third of patients received psychotropic polypharmacy; this group contained a higher percentage of males, White patients, and fewer Asian/South Asian patients. They had on average more hospitalizations, a longer hospitalization period, and were more likely to be diagnosed with an impulsive/behavioral disorder, developmental disorder, or bipolar spectrum disorder. They were twice as likely to receive medication for agitation while hospitalized. A regression model identified positive predictors of polypharmacy as having a history of violence and a higher number of psychiatric hospitalizations. Negative predictors included non-White race. The rate of polypharmacy was relatively stable throughout the study time period, and no impact of the COVID-19 pandemic was found.

Implications/conclusions: Pediatric psychiatric polypharmacy is relatively common and may be associated with poorer outcomes. Certain sociodemographic and clinical characteristics may aid clinicians in predicting which youth may be at risk for polypharmacy. Longitudinal studies are indicated to examine outcomes of polypharmacy so that providers can effectively implement judicious prescribing practices in the community.

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来源期刊
CiteScore
4.00
自引率
3.40%
发文量
231
审稿时长
4-8 weeks
期刊介绍: Journal of Clinical Psychopharmacology, a leading publication in psychopharmacology, offers a wide range of articles reporting on clinical trials and studies, side effects, drug interactions, overdose management, pharmacogenetics, pharmacokinetics, and psychiatric effects of non-psychiatric drugs. The journal keeps clinician-scientists and trainees up-to-date on the latest clinical developments in psychopharmacologic agents, presenting the extensive coverage needed to keep up with every development in this fast-growing field.
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