国际收养儿童贫血患病率及危险因素:一项队列研究。

IF 3.2 3区 医学 Q1 PEDIATRICS
Danilo Buonsenso, Ugo Maria Pierucci, Anna Camporesi, Francesca Raffaelli, Maria Chiara Barbieri, Lucia Scarlato, Arianna Turriziani Colonna, Mariella Iademarco, Ilaria Lazzareschi, Piero Valentini
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引用次数: 0

摘要

背景:收养儿童在其原籍国经常经历保健不足、营养不良和接触传染病的情况,容易受到一系列健康问题的影响,其中贫血是一个主要问题,可能导致长期后遗症。我们的目的是调查在罗马“a . Gemelli”polilinico Universitario儿科诊所评估的一组国际收养儿童中与贫血相关的患病率和危险因素。从2007年到2023年。方法:回顾性队列分析。收集每个儿童的人口统计和血液学数据。分类变量之间的相关性采用Pearson或Fisher检验,定量变量和定性变量之间的相关性采用方差分析(ANOVA)进行Bonferroni校正。Hb水平低于-2SD和Hb Z评分的发生结果:969名儿童被纳入研究。与非洲和拉丁美洲相比,亚洲和印度儿童的体重和身高明显较低。与所有其他年龄组相比,11-18岁年龄组的Hb z得分明显较低。在单变量分析中,Hb z分数与黑色皮肤颜色和粪便中寄生虫的存在有关。血红蛋白水平与患者BMI、肌酐水平、胆红素、TSH、FT3、FT4、AST或ALT无关。在单因素分析中,平均红细胞体积(MCV)与到达时年龄、肤色、原产区域、住院时间、铁水平相关。在相同的MCV下,亚洲的Hb高于非洲(p)。结论:环境暴露和遗传倾向之间可能存在复杂的相互作用,影响着被收养儿童的健康结果。照顾国际收养儿童的医疗保健提供者应优先考虑全面的健康评估,包括贫血、营养缺乏和寄生虫感染筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and risk factors of anemia in internationally adopted children: a cohort study.

Background: Adoptive children, who have often experienced inadequate healthcare, malnutrition, and exposure to infectious diseases in their countries of origin, are vulnerable to a range of health problems among which anemia is a major one, potentially leading to long term sequelae. We aimed to investigate the prevalence and risk factors associated with anemia in a cohort of internationally adopted children evaluated at the Pediatric Clinic of the Policlinico Universitario "A. Gemelli" in Rome. between 2007 and 2023.

Methods: Retrospective cohort analysis. Demographic and hematological data were collected for each child. Associations between categorical variables was studied with Pearson's or Fisher's test and between quantitative and qualitative variables with Analysis of Variance (ANOVA) with Bonferroni correction. The occurrence of a Hb level inferior to -2SD and that of presenting together Hb Z score < -2SD for and low ferritin have been considered as a binary outcome and studied with multivariable logistic regression models.

Results: Nine hundred and sixty-nine children have been enrolled. Weight and height were significantly lower in children from Asia and India compared to Africa and Latin America. Hb z-scores were significantly lower in the 11-18 age group compared to all other age groups. In univariate analysis, Hb z-scores were associated with black skin color and the presence of parasites in stool. Hemoglobin levels were not associated with patient BMI, creatinine levels, bilirubin, TSH, FT3, FT4, AST, or ALT. The mean corpuscular volume (MCV) was associated in univariate analysis with age at arrival, skin color, Macro-area of origin, duration of institutional stay, iron levels. At same MCV, Hb was higher in Asia compared to Africa (p < 0.001). 55 patients had both Hb and MCV values below two SD. These patients are predominantly characterized by black skin color and originating from Africa and India.

Conclusions: There is possibly a complex interplay between environmental exposures and genetic predispositions in shaping the health outcomes of adopted children. Healthcare providers who care for internationally adopted children should prioritize comprehensive health assessments that include screening for anemia, nutritional deficiencies, and parasitic infections.

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来源期刊
CiteScore
6.10
自引率
13.90%
发文量
192
审稿时长
6-12 weeks
期刊介绍: Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
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