这些报纸背后的人——劳拉·拉赫蒂和托马斯·帕尔曼。

IF 3.7 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2025-03-15 Epub Date: 2025-03-26 DOI:10.1242/dev.204787

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引用次数: 0

摘要

中脑多巴胺（mDA）神经元退化是帕金森病的主要原因，因此了解mDA神经元产生的机制有助于为未来的治疗提供信息。发表在《发展》杂志上的一篇新论文确定了mDA祖细胞中调节细胞周期退出时间的关键转录因子。该研究还确定了一群具有祖细胞潜能的室管膜细胞。为了了解更多关于这篇论文背后的故事，我们采访了第一作者Laura Lahti和通讯作者Thomas Perlmann，他是瑞典卡罗林斯卡学院的分子发育生物学教授。

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The people behind the papers - Laura Lahti and Thomas Perlmann.

Midbrain dopamine (mDA) neuron degeneration is a major cause of Parkinson's disease, so understanding the mechanisms underpinning mDA neuron production could help inform future treatments. A new paper in Development identifies key transcription factors that regulate the timing of cell cycle exit in mDA progenitors. The study also identifies a population of ependymal cells that exhibit progenitor potential. To learn more about the story behind the paper, we caught up with first author Laura Lahti and corresponding author Thomas Perlmann, Professor in Molecular Developmental Biology at the Karolinska Institute, Sweden.

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

期刊介绍： Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community. Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication. To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.