钙通道作为癌症治疗的药理靶点。

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2025-03-25 DOI:10.1007/s10238-025-01632-z

Xiaozhen Liu, Changyun Feng, Li Yan, Jili Cao, Xinping Zhu, Mingqian Li, Guizhi Zhao

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引用次数: 0

摘要

Ca2+作为生物过程中重要的第二信使，在多种细胞信号通路的调控中起着关键作用。钙信号的失调与各种癌症的发展有着复杂的联系。Ca2+调节细胞死亡和增殖的能力，以及其潜在的药理学操作，为开发新的癌症治疗方法提供了一条有希望的途径。本文综述了Ca2+通道的分类及其在肿瘤发生中的作用机制，探讨了Ca2+阻滞剂在癌症治疗中的应用，并强调了开展进一步临床试验的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Calcium channels as pharmacological targets for cancer therapy.

Ca²⁺, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca²⁺ to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca²⁺ channels and their mechanisms of action in oncogenesis, explores the application of Ca²⁺ blockers in cancer treatment, and underscores the importance of conducting further clinical trials.

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来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.