肿瘤与其细胞环境间的串扰——在肿瘤进展中的作用。

IF 5.1 2区生物学 Q2 CELL BIOLOGY

Cells Pub Date : 2025-03-10 DOI:10.3390/cells14060403

Eliza Turlej, Aleksandra Domaradzka, Justyna Radzka, Dominika Drulis-Fajdasz, Julita Kulbacka, Agnieszka Gizak

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引用次数: 0

摘要

肿瘤微环境是一个动态的、复杂的三维网络，由细胞外基质和多种非癌细胞组成，包括成纤维细胞、脂肪细胞、内皮细胞和各种免疫细胞（淋巴细胞T和B、NK细胞、树突状细胞、单核/巨噬细胞、髓源性抑制细胞和先天淋巴样细胞）。越来越多的研究强调了这些细胞在塑造癌症存活、转移潜力和治疗耐药性方面的关键作用。本文综述了目前关于细胞微环境在癌症进展和治疗反应中的调节作用的知识。

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Cross-Talk Between Cancer and Its Cellular Environment-A Role in Cancer Progression.

The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix and diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells and various immune cells (lymphocytes T and B, NK cells, dendritic cells, monocytes/macrophages, myeloid-derived suppressor cells, and innate lymphoid cells). A constantly and rapidly growing number of studies highlight the critical role of these cells in shaping cancer survival, metastatic potential and therapy resistance. This review provides a synthesis of current knowledge on the modulating role of the cellular microenvironment in cancer progression and response to treatment.

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来源期刊

Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

9.90

自引率

5.00%

发文量

3472

审稿时长

16 days

期刊介绍： Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.