IF 5.3 2区 医学 Q1 ONCOLOGY
Zhiyong Tan, Chadanfeng Yang, Shi Fu, Junchao Wu, Yinglong Huang, Haihao Li, Chen Gong, Dihao Lv, Jiansong Wang, Mingxia Ding, Haifeng Wang
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引用次数: 0

摘要

迁移体(Migrasomes)是一种新发现的细胞外囊泡(EV),在细胞迁移过程中形成,在细胞间通信中发挥着关键作用。这些囊泡由迁移细胞的回缩纤维产生,包裹着蛋白质、脂质和 RNA 等各种分子,可将生化信号传递给邻近细胞。目前的证据表明,迁移体参与了胚胎发育、血管生成、免疫调节和线粒体质量控制等一系列生理过程。此外,迁移体还与癌症转移、心血管疾病和病毒感染等病理情况有关。要充分了解它们的意义,首先必须探索其形成和功能的分子机制。最近的研究揭示了迁移体的生物生成、释放和生物特性,所有这些都是了解迁移体在细胞间通讯中作用的关键。在这篇综述中,我们对迁移体的生物发生、释放、特征及其在细胞间通讯中的生物活性进行了最新总结,同时还提出了这些囊泡的潜在新功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Migrasomes, critical players in intercellular communication.

Migrasomes are a newly discovered type of extracellular vesicle (EV) formed during cell migration, playing a pivotal role in intercellular communication. These vesicles are generated by retracting fibers of migrating cells and encapsulate various molecules, such as proteins, lipids, and RNA, allowing the transfer of biochemical signals to neighboring cells. Current evidence suggests that migrasomes are involved in a wide range of physiological processes such as embryogenesis, angiogenesis, immune modulation, and mitochondrial quality control. Moreover, migrasomes are implicated in pathological conditions, including cancer metastasis, cardiovascular diseases, and viral infections. To fully understand their significance, it is critical to first explore the molecular mechanisms underlying their formation and function. Recent studies have shed light on the biogenesis, release, and biological properties of migrasomes, all of which are key to understanding their role in cell-to-cell communication. In this review, we provide an up-to-date summary of migrasome biogenesis, release, characterization, and their biological activities in intercellular communication, while also proposing potential new functions for these vesicles.

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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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